[Impedance Measurement for Non-Erosive Reflux Disease


About this study

This study is being done to determine if people with and without GERD or trouble swallowing have increased esophageal mucosa impedance (food getting into the esophageal tissue).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults ages 18-90
  • Patients with heartburn and no hiatal hernia undergoing clinically indicated endoscopy
  • Patients with heartburn and a hiatal hernia > 3cm undergoing clinically indicated endoscopy
  • Patients undergoing clinically indicated upper endoscopy for indications other than dysphagia or GERD
  • Patients with reflux symptoms, a normal appearing esophagus on clinically indicated endoscopy undergoing clinically indicated ambulatory pH/impedance testing.

Exclusion Criteria:

  • Previous gastric or esophageal surgery.
  • Use of proton pump inhibitors 1 month prior to the study
  • Patients on anticoagulation other than aspirin or clopidogrel
  • Presence of erosive esophagitis or Barrett's esophagus

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

David Katzka, M.D.

Closed for enrollment

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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