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Displaying 5 studies

  • Study to Evaluate CORT125134 in Patients With Cushing's Syndrome Rochester, MN

    Cushing's syndrome is a relatively rare disorder caused by prolonged exposure to high levels of the glucocorticoid hormone cortisol. Cushing's syndrome may result from elevated endogenous or exogenous sources of cortisol. Endogenous Cushing's syndrome resulting from cortisol overproduction by the adrenal glands is the subject of this protocol. Patients with exogenous Cushing's syndrome, which develops as a side effect of chronic administration of high doses of glucocorticoids, are not eligible for enrollment in this study. The purpose of this study is to evaluate the safety and efficacy of CORT125134 for treatment of endogenous Cushing's syndrome. The multicenter study will be ...

  • Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery Rochester, MN

    This study will investigate the potential for FK506 binding protein 5 (FKBP5) (and other gene expression markers, for example pentraxin 3 [PTX-3], serum/glucocorticoid regulated kinase 1 [SGK1], and glycogen synthase kinase 3 beta [GSK3b]) to be developed as a biomarker for use in diagnosis of Cushing's syndrome, assessment of effectiveness of medical or surgical treatment, and detection of relapse of endogenous Cushing's syndrome after surgery.

  • A Study of ATR-101 for the Treatment of Cushing’s Syndrome Rochester, MN

    The purpose of this study is to evaluate the effectiveness and safety of  ATR-101 for the treatment of adults who have internally caused Cushings syndrome.

  • A Study of the Characteristics of Adrenal Steroid Production and Metabolism in Patients with Adrenal Tumors, Using Comprehensive Steroid Profiling Rochester, MN

    The purpose of this study is to characterize adrenal steroid synthesis and metabolism in patients with nonfunctioning adrenal tumors (NF), adrenal tumors with subclinical Cushing Syndrome (SCS) and Cushing Syndrome (CS). The study also aims to characterize altered metabolites and disruptive metabolic pathways, and to connect adrenalectomy-induced changes in β-cell function and insulin sensitivity with the preoperative metabolic profile in patients who have NF, SCS and CS adrenal tumors.

  • Prospective Study of Adrenal Disorders: Clinical Registry, Imaging Analysis and Biomaterial Collection Rochester, MN

    The purpose of this research is to follow people with adrenal disorders in order to make conclusions about the natural history of a particular adrenal disease as well as effect of various therapies and interventions decided on by you and your medical team. In addition, we will collect biomaterial from you at times you are being evaluated which will be used to discover novel biomarkers which can potentially improve the accuracy of current diagnostic tests and affect the management of patients with adrenal disorders. We will also include a control group (without known adrenal disease) to compare to the volunteers ...

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