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An electron micrograph and corresponding fluorescence light micrograph of a junction between two pancreatic tumor cells forming vesicular caveolae (arrows) that internalize cell-cell borders allowing the cells to separate and invade. Green is a stain for the caveolin protein.
The cytoplasm (red) and nuclei (blue) of pancreatic cancer cells are invading through a porous filter in culture.
A light micrograph of migrating pancreatic tumor cells stained for actin filaments and a small GTPase activating protein Vav1
These cellular organelles — the autophagolysosome (AP-LY), the lipid droplet (LD) and the mitochondria (MITO) — are often in close proximity to each other and work synergistically.
Hepatocytes cultured from rats fed a control diet (left) have far fewer lipid droplets (red) than hepatocytes cultured from rats fed a diet containing alcohol for six weeks (right). DNA/nucleus is in blue.
The Cytoskeletal Membrane Dynamics Lab is studying how the metastatic behavior of tumor cells is regulated to discover new treatments for pancreatic cancer.
Dr. McNiven's research team is discovering the basic mechanisms by which liver cells utilize stored fat and how a deficit in lipid droplet breakdown causes fatty liver disease.
The Cytoskeletal Membrane Dynamics Lab studies how alcohol contributes to defective lipid droplet breakdown, which causes liver damage.
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