Cytoskeletal Membrane Dynamics: Mark A. McNiven

Membrane trafficking in tumor cell growth: Vesicle transport of growth factor receptors and cell surface components contributes to tumor cell growth
An electron micrograph and corresponding fluorescence light micrograph of a junction between two pancreatic tumor cells forming vesicular caveolae (arrows) that internalize cell-cell borders allowing the cells to separate and invade. Green is a stain for the caveolin protein.
Pancreatic tumor cells grow and invade during metastasis
The cytoplasm (red) and nuclei (blue) of pancreatic cancer cells are invading through a porous filter in culture.
Tumor cells detach and migrate during invasion
A light micrograph of migrating pancreatic tumor cells stained for actin filaments and a small GTPase activating protein Vav1
Cellular organelles essential to regulation of hepatocyte fat metabolism
These cellular organelles — the autophagolysosome (AP-LY), the lipid droplet (LD) and the mitochondria (MITO) — are often in close proximity to each other and work synergistically.
The cellular basis of fatty liver disease: Hepatocytes accumulate lipid droplets when exposed to alcohol
Hepatocytes cultured from rats fed a control diet (left) have far fewer lipid droplets (red) than hepatocytes cultured from rats fed a diet containing alcohol for six weeks (right). DNA/nucleus is in blue.

Membrane trafficking in tumor cell growth: Vesicle transport of growth factor receptors and cell surface components contributes to tumor cell growth