Dr. McNiven has published numerous scientific articles based on research in his Membrane Trafficking in Disease Laboratory. These publications focus on the cellular mechanisms causing pancreatic and liver cancer metastasis, including lipid droplet breakdown in the liver, epidermal growth factor overexpression and processes by which tumor cells degrade the extracellular matrix.

Featured publications

Thomes PG, Strupp MS, Donohue TM Jr, Kubik JL, Sweeney S, Mahmud R, Schott MB, Schulze RJ, McNiven MA, Casey CA. Hydroxysteroid 17β-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis. Journal of Biological Chemistry. 2023; doi:10.1016/jbc.2023.103071.

Burton KM, Johnson KM, Krueger EW, Razidlo GL, McNiven MA. Distinct forms of the actin cross-linking protein α-actinin support macropinosome internalization and trafficking. Molecular Biology of the Cell. 2021; doi:10.1091/mbc.E20-12-0755.

Cao H, Qiang L, Chen J, Johnson KM, McNiven MA, Razidlo GL. Synergistic metalloproteinase-based remodeling of matrix by pancreatic tumor and stromal cells. PLOS One. 2021; doi:10.1371/journal.pone.0248111.

Schulze RJ, Krueger EW, Weller SG, Johnson KM, Casey CA, Schott MB, McNiven MA. Direct lysosome-based autophagy of lipid droplets in hepatocytes. PNAS. 2020; doi:10.1073/pnas.2011442117.

Drizyte-Miller K, Chen J, Cao H, Schott MB, McNiven MA. The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling. Journal of Cell Science. 2020; doi:10.1242/jcs.236661.

Cao H, Krueger EW, Chen J, Drizyte-Miller K, Schulz ME, McNiven MA. The anti-viral dynamin family member MxB participates in mitochondrial integrity. Nature Communications. 2020; doi:10.1038/s41467-020-14727-w.

Burton KM, Cao H, Chen J, Qiang L, Krueger EW, Johnson KM, Bamlet WR, Zhang L, McNiven MA, Razidlo GL. Dynamin 2 interacts with α-actinin 4 to drive tumor cell invasion. Molecular Biology of the Cell. 2020; doi:10.1091/mbc.E19-07-0395.

Li Z, Weller SG, Drizyte-Miller K, Chen J, Krueger EW, Mehall B, Casey CA, Cao H, McNiven MA. Maturation of lipophagic organelles in hepatocytes is dependent upon a rab10/dynamin-2 complex. Hepatology. 2020; doi:10.1002/hep.31059.

Schott MB, Weller SG, Schulze RJ, Krueger EW, Drizyte-Miller K, Casey CA, McNiven MA. Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes. Journal of Cell Biology. 2019; doi:10.1083/jcb.201803153.

Qiang L, Cao H, Chen J, Weller SG, Krueger EW, Zhang L, Razidlo GL, McNiven MA. Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1. Journal of Cell Biology. 2019; doi:10.1083/jcb.201802032.

Razidlo GL, Burton KM, McNiven MA. Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42. Journal of Biological Chemistry. 2018; doi:10.1074/jbc.RA118.003276.

Schulze RJ, Rasineni K, Weller SG, Schott MB, Schroeder B, Casey CA, McNiven MA. Ethanol exposure inhibits hepatocyte lipophagy by inactivating the small guanosine triphosphatase Rab7. Hepatology Communications. 2017; doi:10.1002/hep4.1021.

Schott MB, Rasineni K, Weller SG, Schulze RJ, Sletten AC, Casey CA, McNiven MA. β-adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure. Journal of Biological Chemistry. 2017; doi:10.1074/jbc.M117.777748.

Li Z, Schulze RJ, Weller SG, Krueger EW, Schott MB, Zhang X, Casey CA, Liu J, Stöckli J, James DE, McNiven MA. A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Science Advances. 2016; doi:10.1126/sciadv.1601470.

Cao H, Eppinga RD, Razidlo GL, Krueger EW, Chen J, Qiang L, McNiven MA. Stromal fibroblasts facilitate cancer cell invasion by a novel invadopodia-independent matrix degradation process. Oncogene. 2016; doi:10.1038/onc.2015.163.

Razidlo GL, Magnine C, Sletten AC, Hurley RM, Almada LL, Fernandez-Zapico ME, Ji B, McNiven MA. Targeting pancreatic cancer metastasis by inhibition of Vav1, a driver of tumor cell invasion. Cancer Research. 2015; doi:10.1158/0008-5472.CAN-14-3103.

Inoue J, Krueger EW, Chen J, Cao H, Ninomiya M, McNiven MA. HBV secretion is regulated through the activation of endocytic and autophagic compartments mediated by Rab7 stimulation. Journal of Cell Science. 2015; doi:10.1242/jcs.158097.

Schroeder B, Schulze RJ, Weller SG, Sletten AC, Casey CA, McNiven MA. The small GTPase Rab7 as a central regulator of hepatocellular lipophagy. Hepatology. 2015; doi:10.1002/hep.27667.

Razidlo GL, Schroeder B, Chen J, Billadeau DD, McNiven MA. Vav1 as a central regulator of invadopodia assembly. Current Biology. 2014; doi:10.1016/j.cub.2013.11.013.

Schulze RJ, Weller SG, Schroeder B, Krueger EW, Chi S, Casey CA, McNiven MA. Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes. Journal of Cell Biology. 2013; doi:10.1083/jcb.201306140.

Razidlo GL, Wang Y, Chen J, Krueger EW, Billadeau DD, McNiven MA. Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1. Developmental Cell. 2013; doi:10.1016/j.devcel.2013.02.010.

Wang Y, McNiven MA. Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex. Journal of Cell Biology. 2012; doi:10.1083/jcb.201105153.

Cao H, Krueger EW, McNiven MA. Hepatocytes internalize trophic receptors at large endocytic "Hot Spots". Hepatology. 2011; doi:10.1002/hep.24572.

Wang Y, Cao H, Chen J, McNiven MA. A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src. Molecular Biology of the Cell. 2011; doi:10.1091/mbc.E10-09-0785.

Kurklinsky S, Chen J, McNiven MA. Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons. Journal of Neurochemistry. 2011; doi:10.1111/j.1471-4159.2011.07169.x.

Weller SG, Capitani M, Cao H, Micaroni M, Luini A, Sallese M, McNiven MA. Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2. PNAS. 2010; doi:10.1073/pnas.0915123107.

Cao H, Chen J, Krueger EW, McNiven MA. Src-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin. Molecular and Cellular Biology. 2010; doi:10.1128/MCB.00330-09.

Orlichenko L, Weller SG, Cao H, Krueger EW, Awoniyi M, Beznoussenko G, Buccione R, McNiven MA. Caveolae mediate growth factor-induced disassembly of adherens junctions to support tumor cell dissociation. Molecular Biology of the Cell. 2009; doi:10.1091/mbc.e08-10-1043.

Kruchten AE, Krueger EW, Wang Y, McNiven MA. Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions. Journal of Physiology — Cell Physiology. 2008; doi:10.1152/ajpcell.00238.2008.

Singh VP, McNiven MA. Src-mediated cortactin phosphorylation regulates actin localization and injurious blebbing in acinar cells. Molecular Biology of the Cell. 2008; doi:10.1091/mbc.e07-11-1130.

Cao H, Chen J, Awoniyi M, Henley JR, McNiven MA. Dynamin 2 mediates fluid-phase micropinocytosis in epithelial cells. Journal of Cell Science. 2007; doi:10.1242/jcs.010686.

Orth JD, Krueger EW, Weller SG, McNiven MA. A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization. Cancer Research. 2006; doi:10.1158/0008-5472.CAN-05-2916.

Orlichenko L, Huang B, Krueger E, McNiven MA. Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. Journal of Biological Chemistry. 2006; doi:10.1074/jbc.M512088200.

Cao H, Weller S, Orth JD, Chen J, Huang B, Chen JL, Stamnes M, McNiven MA. Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nature Cell Biology. 2005; doi:10.1038/ncb1246.

Yao Q, Chen J, Cao H, Orth JD, McCaffery JM, Stan RV, McNiven MA. Caveolin-1 interacts directly with dynamin-2. Journal of Molecular Biology. 2005; doi:10.1016/j.jmb.2005.02.003.

Pitts KR, McNiven MA, Yoon Y. Mitochondria-specific function of the dynamin family protein DLP1 is mediated by its C-terminal domains. Journal of Biological Chemistry. 2004; doi:10.1074/jbc.M405531200.

Thompson HM, Cao H, Chen J, Euteneuer U, McNiven MA. Dynamin 2 binds gamma-tubulin and participates in centrosome cohesion. Nature Cell Biology. 2004; doi:10.1038/ncb1112.

Krueger EW, Orth JD, Cao H, McNiven MA. A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells. Molecular Biology of the Cell. 2003; doi:10.1091/mbc.e02-08-0466.

Cao H, Orth JD, Chen J, Weller SG, Heuser JE, McNiven MA. Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Molecular and Cellular Biology. 2003; doi:10.1128/MCB.23.6.2162-2170.2003.

Thompson HM, Skop AR, Euteneuer U, Meyer BJ, McNiven MA. The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis. Current Biology. 2002; doi:10.1016/s0960-9822(02)01390-8.

Abdulkarim AS, Cao H, Huang B, McNiven MA. The large GTPase dynamin is required for hepatitis B virus protein secretion from hepatocytes. Journal of Hepatology. 2003; doi:10.1016/s0168-8278(02)00326-4.

Accola MA, Huang B, Al Masri A, McNiven MA. The antiviral dynamin family member, MxA, tubulates lipids and localizes to the smooth endoplasmic reticulum. Journal of Biological Chemistry. 2002; doi:10.1074/jbc.M201641200.

Orth JD, Krueger EW, Cao H, McNiven MA. The large GTPase dynamin regulates actin comet formation and movement in living cells. PNAS. 2002; doi:10.1073/pnas.012607899.

Yoon Y, Pitts KR, McNiven MA. Mammalian dynamin-like protein DLP1 tubulates membranes. Molecular Biology of the Cell. 2001; doi:10.1091/mbc.12.9.2894.

McNiven MA, Kim L, Krueger EW, Orth JD, Cao H, Wong TW. Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape. Journal of Cell Biology. 2000; doi:10.1083/jcb.151.1.187.

Cao H, Thompson HM, Krueger EW, McNiven MA. Disruption of Golgi structure and function in mammalian cells expressing a mutant dynamin. Journal of Cell Science. 2000; doi:10.1242/jcs.113.11.1993.

Pitts KR, Yoon Y, Krueger EW, McNiven MA. The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells. Molecular Biology of the Cell. 1999; doi:10.1091/mbc.10.12.4403.

Cao H, Garcia F, McNiven MA. Differential distribution of dynamin isoforms in mammalian cells. Molecular Biology of the Cell. 1998; doi:10.1091/mbc.9.9.2595.

Henley JR, Krueger EW, Oswald BJ, McNiven MA. Dynamin-mediated internalization of caveolae. Journal of Cell Biology. 1998; doi:10.1083/jcb.141.1.85.

Yoon Y, Pitts KR, Dahan S, McNiven MA. A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells. Journal of Cell Biology. 1998; doi:10.1083/jcb.140.4.779.

Jones SM, Howell KE, Henley JR, Cao H, McNiven MA. Role of dynamin in the formation of transport vesicles from the trans-Golgi network. Science. 1998; doi:10.1126/science.279.5350.573.

Henley JR, McNiven MA. Association of a dynamin-like protein with the Golgi apparatus in mammalian cells. Journal of Cell Biology. 1996; doi:10.1083/jcb.133.4.761.

Cook TA, Urrutia R, McNiven MA. Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues. PNAS. 1994; doi:10.1073/pnas.91.2.644.