Cytogenetics Core


  • 507-284-0128
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  • For clinical questions, please call the Clinical Cytogenetics Lab at 507-284-2950

The Cytogenetics Core at Mayo Clinic provides cytogenetic and molecular cytogenetic analysis of human and animal model research samples.

These samples may be in the form of cultured cells, fresh or frozen tissue, paraffin-embedded sections, or tissue microarrays. Among other cell types, the core works with tumor cell lines, xenograft cells, hybrid cells from chimeric animal models, neural stem cells and mouse embryonic fibroblasts.

Specialized services offered include cell culture, routine cytogenetic analysis, interphase and metaphase DNA and RNA fluorescence in situ hybridization (FISH), spectral karyotyping analysis of human and mouse metaphases, and homebrew FISH probe production.

Cytogenetics Core personnel, who are highly trained in both cytogenetic and molecular genetic techniques, have the scientific interest and technical ability to incorporate many molecular cytogenetics methods into the core's services. Many scientists at the forefront of cancer genetics research require these services to advance their research.

As cytogenetics-related services are expensive — in terms of both equipment and trained personnel — to incorporate into each investigator's laboratory, the Cytogenetics Core provides researchers at Mayo Clinic in Rochester, Minn., and elsewhere with centrally located cytogenetics expertise and instrumentation.

The Cytogenetics Core, directed by Patricia T. Greipp, D.O., is also a shared resource of the Mayo Clinic Cancer Center.