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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 14 for Knee replacement

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  • Study status: Open/Status Unknown
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  1. RCT Comparing Robotically-Assisted vs. Manually-Executed Total Knee Arthroplasties

    Rochester, MN, Scottsdale/Phoenix, AZ

  2. Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

    Scottsdale/Phoenix, AZ

  3. A Study of Giving Celecoxib and Dexamethasone with Manipulation Under Anesthesia to Treat Postoperative Stiffness after Total Knee Replacement Surgery

    Rochester, MN

  4. A Study to Evaluate Functional Predictive Value of Collective Outcome Measure(s) Status Post Total Hip/Knee Arthroplasty

    Jacksonville, FL

  5. Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

    Rochester, MN

  6. A Study to Evaluate Preventative Saphenous Nerve Neurectomy in Primary Total Knee Arthroplasty

    Jacksonville, FL

  7. A Study to Assess Outcomes of Operatively-treated Interprosthetic Femur Fractures.

    Rochester, MN

  8. Genetic Expression in Osteolysis, Infection, Arthrofibrosis & Metal Reactions in THA & TKA: A Microarray Analysis to Characterize Individual Host Response to the Molecular Mechanisms of Loosening and Arthrofibrosis

    Rochester, MN

  9. A Study to Evaluate Manipulation Under Anesthesia After Bilateral Primary Total Knee Arthroplasty

    Rochester, MN

  10. A Study to Evaluate A Patient's Perception of Indwelling Foley Catheters Following Total Hip or Total Knee Arthroplasty

    Jacksonville, FL

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