Clinical Trials

The purpose of this study is to evaluate comparisons between a hybrid program of center-based CR which incorporates mHealth remote case management technology (CON+) to a traditional center-based program alone (CON) as well as comparisons between home-based mHealth remote case management alone (HOM+) to a traditional center-based program (CON).

The main purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen. The two approaches of the same total exercise durston will include: 1) HIIT with progressively increased interval durations (PRO-HIIT) versus 2) HIIT with constant shorter interval durations (CON-HIIT). The study hypothesis is that the progressively increased interval duration at high-intensity (PRO-HIIT) will result in a greater increases in fitness, heart function, and the ability of the body's muscles to receive oxygen in patients enrolled in cardiac rehabilitation. 

The purpose of this study is to compare resting blood pressure, heart rate, and quality of life outcomes in cardiac rehab patients with canine involvement versus traditional cardiac rehab therapy alone.

The purpose of this study is to evaluate the impact of interventions on important CV biomarkers to provide valuable information on the mechanism linking depression and anxiety to cardiac prognosis resulting in improved quality of life and diagnosis.

We are currently enrolling both healthy volunteers and people who have been diagnosed with heart failure to participate in our research study.  The purpose of this study is to better understand the relationship between exercise, breathing, blood flow and blood pressure.  This study includes two study visits if you are a healthy or heart failure volunteer.    All testing will be performed at our testing center at St. Mary’s Hospital located in Rochester, MN. 

On the first study visit, the research activities will be discussed and all questions will be answered. Once written consent is provided and the participant is enrolled, lung function and exercise capacity will be measured.

The second study visit includes two separate breathing muscle workouts (a light and moderate workload) each followed by 10 min of light to moderate cycling exercise. In addition, two breathing tests will also be performed. During this visit, blood is drawn during exercise.

If you are a patient at Mayo Clinic, who is currently enrolled or will be enrolling in a cardiac rehabilitation exercise program, you will have the option to complete four study visits.  Your first two study visits as described above will be completed at the beginning of cardiac rehabilitation and then we will ask you to return to complete those same two study visits following the completion of your cardiac rehabilitation program.

Remuneration and parking reimbursement are provided.

Cardiopulmonary rehabilitation (CP rehab) with an exercise component is important in the care from many people with heart or lung disease. Measuring the benefits of CP rehab (i.e., measuring ‘how well CP rehab works’) depends upon having tests or ‘tools’ that can very well detect positive changes in physical and clinical function. One such tool is maximal cardiopulmonary exercise testing (CPET). This is the gold standard for measuring exercise capacity. However, maximal CPET is expensive, has extensive set-up and space requirements, needs direct medical supervision, and involves interpretive complexity; these factors have limited the widespread use of maximal CPET as an outcome measurement tool in CP rehab programs.

We and others have shown that measures of breathing and how gases (i.e., oxygen and carbon dioxide) exchange at the lungs during short submaximal exercise can be used to identify pulmonary and/or cardiac abnormalities. For the present research, we are theorizing that any before to after CP rehab improvements in general cardiopulmonary function and the cardiopulmonary responses to exercise should be reflected in the breathing and gas exchange responses to submaximal exercise. As such, the key objective of this research is to examine the cardiopulmonary responses to a short, incremental but submaximal exercise test (iCPET) in patients before and after completion of a standard cardiopulmonary rehabilitation program. In doing so, the proposed research may identify submaximal exercise testing as a useful adjunct outcome assessment tool in the setting of CP Rehab.

The objectives of this study are to examine the prevalence of comorbid sleep disordered breathing (SDB) and insomnia in post-MI patients enrolled in cardiac rehabilitation (CR), to assess whether post-MI CR patients with comorbid SDB and insomnia exhibit a more unfavorable CV profile than those without, and to determine whether post-MI CR patients with comorbid SDB and insomnia show less adherence to home-based CR than those without.

The purpose of this study is to describe the clinical impact of cardiac rehabilitation in patients who have undergone myectomy for hypertrophic cardiomyopathy.  Compare the clinical outcomes of patients who have attended cardiac rehab with those who have not attended after myectomy for hypertrophic cardiomyopathy. 

The purpose of this study is to measure overall activity (sedentary-to-high intensity) during rehab and at 1 year follow-up.  

The purpose of this study is to determine if patients enrolled in the cardiac rehabilitation program can accurately self-assess their 6 minute walk test (6MWT), waist circumference (WC), handgrip strength (HGS), leg strength, and flexibility compared to the cardiac rehabilitation staff.