Cardiac Rehabilitation in Heart Failure With Mitochondrial Adaptation To High-intensity Interval Training


About this study

The purpose of this study is to examine PRO-HIIT compared with CON-HIIT on effectiveness for improving locomotor muscle mitochondrial function in heart failure (HF) patients.


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult 21 years and older.
  • English speaking.
  • Able to provide consent.
  • Clinically diagnosed stable heart failure with NYHA Class I-III symptoms.

Exclusion Criteria: 

  • Patients who are unable to engage in a regularly structured exercise training program.
  • History of dangerous arrhythmias.
  • BMI > 40 kg/m^2
  • Current smokers or smoking history of > 20 pack years
  • Pregnant women, implanted pacemaker and/or ICD, cochlear implants, drug infusion pump, or any other implanted metal objects.

Eligibility last updated 8/8/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Thomas Olson, Ph.D., M.S.

Open for enrollment

Contact information:

Salaheddin Sharif M.B., Ch.B., Ph.D.

(507) 255-1572

More information


Publications are currently not available

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