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(for at least one location)
Describes the nature of a clinical study. Types include:
The primary purpose of this study is to describe the utilization and findings on magnetic resonance imaging (MRI) of the hands and feet in patients with seronegative rheumatoid arthritis (RA) (based on the ACR 1987 or 2010 classification criteria) compared to the findings seen in patients with seropositive disease (RF or ACPA positive).
Study statuses change often. Please contact us for help.
Open for enrollment
The primary objective of this study is to determine the impact of ArthritisPower™ integration into the clinical evaluation of patients with RA on the primary endpoint of clinical improvement as defined by the continuous change in the Clinical Disease Activity Index.
This study is designed to:
-analyze effects of surgical treatment
-improve surgical care and quality of life of patients with hip problems/diseases
-ID predictors of surgical outcomes to identify/improve future treatments
-Collect data, images, from patients undergoing surgical treatment of hip disorders (we will not be collecting social security numbers to send to Washington University).
The purpose of this study is to determine the safety and feasibility of autologous, adipose derived stromal vascular fraction injections in the treatment of knee osteoarthritis.
The purpose of this pilot study is to analyze the effectiveness of a new ultrasound microvessel imaging technology for evaluation of synovitis in patients with rheumatoid arthritis.
This study is being conducted to determine gene and protein expression profiles (i.e. which genes and proteins are turned off and on) of those with a possibility of developing osteolysis, infection, arthrofibrosis or metallosis of their THA/TKA.
The purpose of this study is to establish the immunometabolic profile of T cells isolated from patients with Rheumatoid Arthritis/Interstitial Lung Disease (RA/ILD), to identify distinguishing features in the metabolic status of T cells from RA patients with and without ILD, and to explore the use of immunometabolic determinants as a biomarker in RA patients with and without ILD.
Rochester, MN, Minneapolis, MN
The purpose of this study is to investigate a case series of patients treated with Platelet-rich plasma for thumb carpometacarpal joint osteoarthritis. CMC arthritis is a highly prevalent condition with significant effects on quality of life and function. Meanwhile, platelet-rich plasma has been demonstrated to be an effective treatment for various musculoskeletal conditions.
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Rheumatoid arthritis (RA) patients have a higher prevalence of subclinical atherosclerosis than the general population. In addition, they experience higher rates of heart failure with preserved ejection fraction (HFpEF). There is evidence that myocardial mechanics and left ventricular diastolic function are more abnormal in the RA population and these changes occur earlier than in the general population. Recently a study suggested that RA patient have abnormal myocardial inflammation during a disease flare and that this is improved with anti-inflammatory treatment. Our study is aimed at describing the prevalence of myocardial inflammation in patients during active RA disease flares and comparing that with RA patients who are in remission. We hope to show that abnormalities in myocardial inflammation on PET imaging correlate with abnormalities in myocardial strain on echocardiography. Coronary CT will be performed to establish the presence of subclinical atherosclerosis and whether its presence affects changes in either myocardial inflammation or myocardial strain. The hypothesis is that patients with evidence of myocardial inflammation during the course of their RA disease are more likely to develop HFpEF during their lifetime. Although the present study will not be of a duration to assess outcome, we will provide descriptive data which may help guide future prospective study of patients with RA which may help guide appropriate cardiovascular testing in this high risk population.
The purpose of this study is to systematically examine the immunological features between IA-irAE, classic inflammatory arthritis, ICI-controls and HC.
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