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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 11-19 of 19 for

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  • Study status: Open/Status Unknown
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  1. Exploring the Role of B-cell Activating Factor Receptor (BAFFR)-based Chimeric Antigen Receptor T-cell (CAR T) in BAFFR-expressing B-cell Hematologic Malignancies and Autoimmune Rheumatologic Disorders

    Jacksonville, FL

  2. Ultrasound Evaluation of Synovitis

    Rochester, MN

  3. Genetic Expression in Osteolysis, Infection, Arthrofibrosis & Metal Reactions in THA & TKA: A Microarray Analysis to Characterize Individual Host Response to the Molecular Mechanisms of Loosening and Arthrofibrosis

    Rochester, MN

  4. A Study to Identify Biomarkers in Patients with Rheumatoid Arthritis and Interstitial Lung Disease

    Rochester, MN

  5. A Study to Evaluate Immune Features of Inflammatory Arthritis As It Correlates with Imbalance Between T-cell Exhaustion and Senescence

    Rochester, MN

  6. A Study to Evaluate Inflammation of the Heart Muscle Tissue in Patients with Rheumatoid Arthritis

    Rochester, MN

  7. Somatic Mutation in Rheumatoid Arthritis

    Rochester, MN

  8. A Study to Assess Wrist Range of Motion via Telemedicine

    Jacksonville, FL

  9. A Study to Assess Biomarkers in Patients with Osteonecrosis of the Femoral Head

    Rochester, MN

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