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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 33 for Epilepsy

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  • Study status: Open/Status Unknown
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  1. A Study to Evaluate fMRI of Active Deep Brain Stimulation in Epilepsy

    Jacksonville, FL

  2. A Study to Test the Effectiveness and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects with Drug-resistant Epilepsy

    Rochester, MN

  3. An Open-Label Study to Investigate the Safety and Pharmacokinetics of Single Ascending Doses of Antisense Oligonucleotide STK-001 in Children and Adolescents with Dravet Syndrome

    Rochester, MN

  4. Study of Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy

    Rochester, MN

  5. A Study to Evaluate Feasibility of Microburst Vagus Nerve Stimulator (VNS) Therapy

    Jacksonville, FL

  6. Stereotactic Laser Ablation for Temporal Lobe Epilepsy

    Rochester, MN

  7. A Study of the Thalamus Using Deep Electrode EEG to Better Understand its Participation in the Beginning or Spreading of Seizures

    Rochester, MN

  8. A Study to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection Using Intraoperative Brain Microdialysis

    Rochester, MN

  9. Medtronic Deep Brain Stimulation (DBS) Therapy for Epilepsy Post-Approval Study (EPAS)

    Rochester, MN

  10. Study of the Incidence of Electrographic Status Epilepticus and Seizures of PICU Patients at National Children’s Hospital in Hanoi, Vietnam.

    Rochester, MN

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