A Study to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection Using Intraoperative Brain Microdialysis


About this study

The purpose of this study is to measure the space and time characteristics of inflammatory mediator release in response to induced epileptiform activity in ASD-resistant patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

Inclusion Criteria:

  • Failure to respond to at least two trials of anti-seizure drugs with different mechanisms of action;
  • Normal MRI.

Exclusion Criteria: 

  • Active immunomodulatory therapy;
  • Autoimmune disorder;
  • Signs or symptoms consistent with comorbid infection;
  • ncological comorbidity.


Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Charles Howe, Ph.D.

Open for enrollment

Contact information:

Karla Crockett



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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