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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 56 for Pulmonary hypertension

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  1. Investigation of the Safety and Pharmacology of Dry Powder Inhalation of Treprostinil

    Rochester, MN

  2. A Study of Macitentan in Pulmonary Hypertension After Left Ventricular Assist Device Implantation

    Scottsdale/Phoenix, AZ

  3. A Study of Levosimendan in Pulmonary Hypertension (PH) with Heart Failure (HF) and Preserved Left Ventricular Ejection Fraction (pEF) Patients

    Rochester, MN

  4. A Study to Evaluate Whether or Not Selexipag is Effective and Safe in Patients with Chronic Thromboembolic Pulmonary Hypertension when the Disease is Inoperable or Persistent/Recurrent After Surgery

    Jacksonville, FL

  5. Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

    Jacksonville, FL, Rochester, MN

  6. A Study of Ubenimex in Patients with Pulmonary Arterial Hypertension

    Rochester, MN

  7. A Study to Evaluate the Long-term Safety and Tolerability of Inhaled LIQ861(Treprostinil) in Pulmonary Arterial Hypertension Patients

    Jacksonville, FL

  8. A Study of Inhaled GB002 for Treatment of WHO Group I Pulmonary Arterial Hypertension

    Jacksonville, FL

  9. A Study to Evaluate the Safety and Tolerability of TreT in Subjects with PAH Currently Using Tyvaso

    Jacksonville, FL

  10. PORtopulmonary Hypertension Treatment wIth maCitentan ─ a randOmized Clinical Trial

    Rochester, MN

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