Exercise Training to Improve Pulmonary Haemodynamic and Right Ventricular Function in Heart Failure Patients with Pulmonary Hypertension


About this study

The purposed of this study are to investigate whether structured exercise training improves cardiac and pulmonary haemodynamic function, exercise capacity, and short-term clinical outcomes in heart failure (HF) patients with Pulmonary Hypertension (PH), and to develop a multivariable exercise pulmonary gas exchange ‘score’ that accurately differentiates HF patients with pre- and post-capillary PH (CpcPH) from HF patients with isolated post-capillary PH (IpcPH).



Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • NYHA functional class I-IIIb.
  • LVEF < 40%.
  • Clinically-stable for > 3 months [no change in disease status or medication].
  • Willing and able to provide written informed consent and perform cycle-ergometer based exercise.

Exclusion Criteria:

  • NYHA class IV HF.
  • Diagnosis of diastolic HF.
  • Comorbidities such as obesity (BMI > 36), uncontrolled systemic hypertension, type 2 diabetes, and COPD (FEV1 < 50%).
  • Musculoskeletal or other conditions that would limit exercise participation.
  • Pregnant or nursing women.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Bryan Taylor, Ph.D.

Open for enrollment

Contact information:

Bryan Taylor Ph.D.

(904) 953-7274


More information


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