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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 41-50 of 1342 for surgery

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  1. A Study of the Effectiveness of Behavior Therapy on Weight Loss with Bariatric Surgery

    Rochester, MN

  2. Bariatric Surgery Versus Diet Alone in the Bile Acid Pathway and Weight Loss

    Rochester, MN

  3. A Study of the Safety and Effectiveness of Combined Toca 511 and Toca FC for Patients Having Removal Surgery for Recurring Glioblastoma or Anaaplastic Astrocytoma

    Jacksonville, FL

  4. Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil

    Jacksonville, FL

  5. Study to Evaluate Serial Amnioinfusions as Therapy for Pulmonary Hypoplasia in Fetuses with Renal Failure or Severe Renal Anomalies

    Rochester, MN

  6. Perceval S Aortic Heart Valve Study- North America

    Rochester, MN

  7. Automatic Periodic Stimulation and Continuous Electromyography (EMG) for Facial Nerve Monitoring During Parotidectomy

    Rochester, MN

  8. A Study of the Effect of Using MRI and Mammography Before Surgery in Patients with Stage I-II Breast Cancer

    Rochester, MN

  9. A Study to Evaluate the Effectiveness and Safety of D-PLEX in the Prevention of Sternal Infection Post- Cardiac Surgery

    Rochester, MN

  10. Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) Study

    Rochester, MN

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