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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 371-380 of 2028 for surgery

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  1. A Study to Evaluate Chemotherapy and Radiation Therapy With or Without Surgery to Treat Patients With Head and Neck Cancer

    Rochester, MN

  2. Dasatinib in Treating Patients With Locally Advanced or Metastatic Mucosal Melanoma, Acral Melanoma, or Vulvovaginal Melanoma That Cannot Be Removed By Surgery

    Rochester, MN

  3. Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial)

    Rochester, MN

  4. Ipilimumab Or High-Dose Interferon Alfa-2b In Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed By Surgery

    Jacksonville, FL

  5. A Study To Evaluate Testing The Addition Of Targeted Radiation Therapy To Surgery And The Usual Chemotherapy Treatment For Stage I-IIIA Malignant Pleural Mesothelioma

    Rochester, MN

  6. A Study Of The Safety And Effectiveness Of Combined Toca 511 And Toca FC For Patients Having Removal Surgery For Recurring Glioblastoma Or Anaaplastic Astrocytoma

    Jacksonville, FL

  7. A Study to Develop Processes for Tissue Growth for Use in Reconstruction Surgeries

    Scottsdale/Phoenix, AZ

  8. Pediatric And Adolescent Patellar Instability

    Rochester, MN

  9. Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, and Surgical Outcomes

    Scottsdale/Phoenix, AZ

  10. A Study To Evaluate The Efficacy And Safety Of GDC-8264 In Preventing Cardiac Surgery-Associated Acute Kidney Injury (AKI) And Major Adverse Kidney Events (MAKE)

    Rochester, MN

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