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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 371-380 of 2056 for surgery

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  1. Alisertib And Fulvestrant In Treating Patients With Hormone Receptor Positive Breast Cancer That Is Metastatic Or Locally Advanced And Cannot Be Removed By Surgery

    Rochester, MN

  2. Irinotecan And Cetuximab With Or Without Bevacizumab In Treating Patients With RAS Wild-Type Locally Advanced Or Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

    Scottsdale/Phoenix, AZ

  3. Transoral Surgery Followed By Low-Dose Or Standard-Dose Radiation Therapy With Or Without Chemotherapy In Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer

    Scottsdale/Phoenix, AZ

  4. Atezolizumab, Pemetrexed Disodium, Cisplatin, And Surgery With Or Without Radiation Therapy In Treating Patients With Stage I-III Pleural Malignant Mesothelioma

    Scottsdale/Phoenix, AZ, Rochester, MN

  5. Phase III Study To Evaluate The Efficacy And Safety Of The INTERCEPT Blood System For Red Blood Cells In Patients Undergoing Complex Cardiac Surgery Procedures

    Rochester, MN

  6. Intragastric Balloon In Obese Adolescents With Comorbidities

    Rochester, MN

  7. Antiandrogen Therapy And Radiation Therapy With Or Without Docetaxel In Treating Patients With Prostate Cancer That Has Been Removed By Surgery

    Albert Lea, MN, Rochester, MN

  8. Cisplatin And Etoposide Or Temozolomide And Capecitabine In Treating Patients With Neuroendocrine Carcinoma Of The Gastrointestinal Tract Or Pancreas That Is Metastatic Or Cannot Be Removed By Surgery

    Rochester, MN

  9. A Study To Evaluate Gemcitabine, Cisplatin, And Nab-Paclitaxel To Treat Patients With High-Risk Liver Bile Duct Cancer Before Surgery

    Rochester, MN

  10. Comparison Of Acute Toxicities Between Patients Treated With Protons Or Intensity Modulated Radiation Therapy After Surgery For The Treatment Of Endometrial Or Cervical Cancer

    Albert Lea, MN, Scottsdale/Phoenix, AZ, Eau Claire, WI, Jacksonville, FL, La Crosse, WI, Mankato, MN, Rochester, MN

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