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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 261-270 of 2028 for surgery

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  1. A Study to Compare Single Fraction Stereotactic Radiosurgery Compared with Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease

    Jacksonville, FL, Rochester, MN, Scottsdale/Phoenix, AZ

  2. Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

    Scottsdale/Phoenix, AZ

  3. ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

    Rochester, MN

  4. Botulinum Toxin A (Botox) In Tissue Expander Breast Reconstruction

    Rochester, MN

  5. A Study of Pre-Conditioning Prior to Surgery to Improve Functional and Clinical Outcomes in Patients with Aortic Stenosis

    Eau Claire, WI, Rochester, MN

  6. A Study of Lusedra (Fospropofol Disodium) for Use as Minimal to Moderate Sedation for Regional Anesthesia Nerve Blockage Prior to Orthopedic Surgery

    Scottsdale/Phoenix, AZ

  7. Cerebrospinal Fluid Biomarkers For Brain Tumors

    Rochester, MN

  8. Ommaya at Biopsy

    Rochester, MN

  9. Grit as a Predictor of Outcomes in Transcatheter Valvular Therapeutic Candidates

    Rochester, MN

  10. A Study of Giving Celecoxib and Dexamethasone with Manipulation Under Anesthesia to Treat Postoperative Stiffness after Total Knee Replacement Surgery

    Rochester, MN

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