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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 251-260 of 2202 for surgery

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  1. Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery

    Rochester, MN

  2. Smoking Cessation Prior to Surgery to Reduce Surgical Complications in Patients With Newly Diagnosed Lung Cancer Who Smoke Cigarettes

    Mankato, MN

  3. Study to Examine the Effect of Gastric Bypass Surgery on Venlafaxine ER Blood Levels

    Rochester, MN

  4. A Study Comparing Combination Chemotherapy to Gemcitabine Hydrochloride and Nab-Paclitaxel Given Before Surgery for Treating Patients who have Pancreatic Cancer that can be Removed by Surgery

    Rochester, MN

  5. Pre-Op / Post-Op Hypofractionation Radiotherapy in Breast Cancer

    Scottsdale/Phoenix, AZ, Jacksonville, FL

  6. A Study to Examine Axillary Reverse Mapping in Preventing Lymphedema in Patients With Breast Cancer Undergoing Axillary Lymph Node Dissection

    Jacksonville, FL

  7. EF-41/KEYNOTE D58: Phase 3 Study Of Optune Concomitant With Temozolomide Plus Pembrolizumab In Newly Diagnosed Glioblastoma

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  8. Transfemoral Replacement Of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial

    Rochester, MN

  9. A Comparison Of TULSA Procedure Vs. Radical Prostatectomy In Participants With Localized Prostate Cancer (CAPTAIN)

    Jacksonville, FL, Rochester, MN

  10. Evaluation Of De-escalated Adjuvant Radiation Therapy For Human Papillomavirus (HPV)-Associated Oropharynx Cancer

    Albert Lea, MN, Scottsdale/Phoenix, AZ, Eau Claire, WI, La Crosse, WI, Mankato, MN, Rochester, MN

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