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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 281-290 of 2195 for surgery

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  1. SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial

    Rochester, MN

  2. ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve

    Rochester, MN

  3. Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

    Rochester, MN

  4. Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction

    Rochester, MN

  5. Sirolimus, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients At High Risk for Cholangiocarcinoma Recurrence After Liver Transplant or Surgery

    Rochester, MN

  6. Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

    Scottsdale/Phoenix, AZ

  7. A Study of Giving Celecoxib and Dexamethasone with Manipulation Under Anesthesia to Treat Postoperative Stiffness after Total Knee Replacement Surgery

    Rochester, MN

  8. Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

    Scottsdale/Phoenix, AZ

  9. A Study to Compare Single Fraction Stereotactic Radiosurgery Compared with Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease

    Jacksonville, FL, Rochester, MN, Scottsdale/Phoenix, AZ

  10. Pre-operative Vs. Post-operative Radiosurgery For Metastatic Brain Tumors

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

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