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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 91-100 of 2195 for surgery

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  1. A Study to Evaluate Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

    Eau Claire, WI, Rochester, MN, La Crosse, WI

  2. A Study to Evaluate the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis to Treat Thoracoabdominal and Pararenal Aortic Aneurysms

    Scottsdale/Phoenix, AZ

  3. A Study to Compare Total Amount of Opioid Use in the First 72 Hours Following Vaginal Hysterectomy Surgery

  4. Correlation of Spinopelvic Movement with Lateral Radiographs to Assess Spine Motion Prior to Total Hip Arthroplasty

    Rochester, MN

  5. A Study Comparing Combinations of Chemotherapy for Treating Women who have Undergone Surgery for Node-Positive Breast Cancer

    Scottsdale/Phoenix, AZ, Jacksonville, FL

  6. Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer

    Scottsdale/Phoenix, AZ

  7. A Study of Clinical Outcomes of Ultrasound-guided Carpal Tunnel Release Performed in a Procedural Room Setting

    Albert Lea, MN

  8. A Study to Assess Cisplatin and Combination Chemotherapy in Treating Children and Young Adults with Hepatoblastoma or Liver Cancer After Surgery

    Rochester, MN

  9. Intragastric Balloon in Obese Adolescents With Comorbidities

    Rochester, MN

  10. RCT Comparing Robotically-Assisted vs. Manually-Executed Total Knee Arthroplasties

    Rochester, MN, Scottsdale/Phoenix, AZ, Jacksonville, FL

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