Pilot Study to Evaluate MR-guided Laser Ablation of Focal Lesions in Patients with Medically Refractory Partial Epilepsy

Overview

About this study

To investigate whether MR-guided laser induced thermal therapy in patients diagnosed with focal lesional epilepsy using the Visualase Thermal Therapy System is both a feasible and safe minimally invasive technique for control of seizures in such patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 18 years or older at entry to protocol.
  • History of MRI lesional-related epilepsy for at least one year.
  • Failure to respond to more than 2 anti-epileptic drugs at adequate dose and duration.
  • Candidate for resective epilepsy surgery.
  • Considered healthy enough to undergo surgery with general anesthesia.
  • The patient has given written informed consent after the nature of the study and alternative treatment options have been explained.
  • Must have 3 months of seizure frequency recorded prior to procedure.

Exclusion Criteria:

  • Presence of any non-MRI compatible implanted electronic device.
  • Presence of a metallic prosthetic or implant including artificial hips, knees, joints, or rods and screws.
  • Active Major depression
  • History of Suicide attempts
  • History of Non-Epileptic Behavioral Spells

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

W Marsh, M.D.

Closed for enrollment

Jacksonville, Fla.

Mayo Clinic principal investigator

W Marsh, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

.
CLS-20123056

Mayo Clinic Footer