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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 11-20 of 531 for sleep

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  1. A Study of a Sleep Health ‘App’ to Help First-Time Users of Positive Airway Pressure Therapy for Sleep Apnea

    Scottsdale/Phoenix, AZ, Rochester, MN

  2. Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

    Scottsdale/Phoenix, AZ

  3. Physiologic Effects of Sleep Restriction

    Rochester, MN

  4. Glasses for Adolescent Delayed Sleep-Wake Phase Disorder (GLAD)

    Rochester, MN

  5. Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA

    Scottsdale/Phoenix, AZ

  6. Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD)

    Rochester, MN

  7. Sleep for Stroke Management and Recovery Trial

    Jacksonville, FL

  8. Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder

    Rochester, MN

  9. A Study to Evaluate the Use of a Smartphone App for Stroke Patients with Obstructive Sleep Apnea

    Rochester, MN

  10. Reflex Responses to Intermittent Hypoxia in Humans

    Rochester, MN

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