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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 54 for pediatric AND surgery

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  1. Reducing Smoke Exposure in Children Facing Surgery

    Rochester, MN

  2. Role of Sildenafil for Fontan Associated Liver Disease (SiFALD) Study

    Rochester, MN

  3. Pediatric and Adolescent Patellar Instability

    Rochester, MN

  4. Combination Chemotherapy, Radiation Therapy, and an Autologous Peripheral Blood Stem Cell Transplant in Treating Young Patients with Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System

    Rochester, MN

  5. Artisan Aphakia Lens for the Correction of Aphakia in Children

    Rochester, MN

  6. A Study of the Practicality and Usefulness of the Ostom-I Alert System with Pediatric Ostomy Patients

    Rochester, MN

  7. Intragastric Balloon in Obese Adolescents With Comorbidities

    Rochester, MN

  8. A Study of the Effect of Treatment on Activity and Muscle Function in Pediatric Patients with Scoliosis

    Rochester, MN

  9. A Study to Assess the Safety and Pharmacokinetics of Subcutaneously Administered Golimumab, a Human Anti-TNFα Antibody, in Pediatric Patients With Moderate to Severe Active Ulcerative Colitis

    Rochester, MN

  10. NIRS Predict Low Cardiac Output State in Neonates and Infants in Cardiac Surgery

    Rochester, MN

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