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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 75 for pain

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  • Study status: Open/Status Unknown
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  1. A Study to Compare HF10 Therapy Combined With CMM to CMM Alone in the Treatment of Non-Surgical Refractory Back Pain

    Scottsdale/Phoenix, AZ

  2. A Study to Evaluate Patient Experience Comparing Tonic vs. Burst Spinal Card Stimulation for Chronic Pain

    Jacksonville, FL

  3. Low-Cost Tool for Compliance and Treatment-Tracking of Low Back Pain Patients

    Rochester, MN

  4. A Study to Compare HF10 Therapy Combined with Conventional Medical Management (CMM) to CMM Alone in the Treatment of Non-Surgical Refractory Back Pain

    Rochester, MN

  5. Dorsal spInal cord STImulatioN vs mediCal management for the Treatment of low back pain

    Rochester, MN

  6. A Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries

    Rochester, MN

  7. A Study of Lofexidine for Rapid Opioid Tapering in Adults

    Rochester, MN

  8. A Study Comparing Effectiveness and Safety of SPIRA-A Anterior Lumbar Interbody Fusion Device to PEEK Anterior Lumbar Interbody Fusion Cage with rhBMP-2 in Instrumented Lumbar Fusions

    Rochester, MN

  9. A Study of the Use of Shear Wave Elastography with an Ultrasound Scanner to Measure Myofascial Trigger Points

    Rochester, MN

  10. Study of Lumbar Discectomy with Additional Implantation of an Annular Closure Device in Patients with Large Postsurgical Annular Defects

    Jacksonville, FL

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