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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 41-50 of 75 for pain

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  • Study status: Open/Status Unknown
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  1. A Study to Implement a Patient-Centered Pain Plan and Standardized Preoperative Pain Education for Patients Undergoing Lumbar Procedures

    Mankato, MN

  2. Spontaneous Coronary Artery Dissection: Mechanistic Evaluation

    Rochester, MN

  3. Clinical Outcomes After Re-operation for Groin Pain due to Inguinal Herniorrhaphy

    Rochester, MN

  4. A Study to Evaluate Long-Term Outcomes of Gastroesophageal Reflux Disease (GERD)

    Rochester, MN

  5. A Study to Establish an Enterprise Neurosurgery Biobank

    Rochester, MN

  6. A Study of Chemotherapy-induced Peripheral Neuropathy in Hodgkin's Lymphoma Patients who Received Brentuximab Vedotin

    Rochester, MN

  7. A Study to Learn About How Women Metabolize and Respond to Opioids When Used for Managing Post-operative Pain

    Rochester, MN

  8. A Study to Evaluate Unintended Prolonged Opioid Use

    Rochester, MN

  9. Pain Severity and Pain Interference Outcomes following Percutaneous MRI-Guided Laser Ablation and Cryoablation of Painful Peripheral, Soft Tissue Vascular Anomali

    Rochester, MN

  10. A Study to Enroll Patients of Rheumatic Diseases and First-degree Relatives in a Biobank

    Rochester, MN, Rochester, MN

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