Spontaneous Coronary Artery Dissection: Mechanistic Evaluation


About this study

The purpose of this study is to screen for unique or characteristic circulating peptides, hormonal biomarkers and circulating mRNA in patients who have experienced spontaneous coronary artery dissection (SCAD).


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Females >= 18 old presenting with an acute coronary syndrome characterized in a standard manner 
    • Chest pain 
    • Abnormal ECG
    • Elevated troponin-t)
  • Pts have undergone coronary angiography within 4 weeks, with one of these three diagnoses obtained: 
    • Spontaneous Coronary Artery Dissection (SCAD)
    • Atherothrombotic acute coronary syndrome
    • Angiographically normal coronary arteries

Exclusion Criteria:

  • Women of childbearing potential who do not agree to use an effective method of birth control while they are enrolled in this study
  • Pregnant women
  • Refusal of consent

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Rajiv Gulati, M.D., Ph.D.

Open for enrollment

Contact information:

Sara Biorn CCRP

(507) 266-2328


More information


Publications are currently not available