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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 31-40 of 835 for cancer

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  1. A Study to Evaluate Immune-related Biomarkers for Pathological Response in Stage II-III HER2-positive Breast Cancer

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  2. A Study of 177Lu-FAP-2286 in Advanced Solid Tumors (LuMIERE)

    Rochester, MN

  3. Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations

    Scottsdale/Phoenix, AZ, Rochester, MN, Jacksonville, FL

  4. A Study to Evaluate Oncologic Outcomes and Quality of Life in Sinonasal Cancer Patients

    Rochester, MN

  5. Safety and Activity of PolyPEPI1018 Plus Atezolizumab in Colorectal Cancer.

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  6. Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  7. A Study to Evaluate Ulixertinib to Treat Patients with Advanced Malignancies Harboring MEK or Atypical BRAF Alterations

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  8. A Study of Selpercatinib Following Definitive Locoregional Treatment in Participants with Non-small Cell Lung Cancer

    Rochester, MN

  9. A Study to Evaluate AB308 in Combination With AB122 in Participants With Advanced Malignancies

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  10. Pembrolizumab in Treating Participants With Recurrent Ovarian Cancer

    Rochester, MN

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