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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 43 for Ophthalmology

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  • Study status: Open/Status Unknown
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  1. A Study Assessing the Effectiveness and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active, Non-Infectious Uveitis of the Posterior Segment of the Eye

    Rochester, MN

  2. A Study of the Effects of Pneumatic Vitreolysis on Macular Hole

    Rochester, MN

  3. A Study to Evaluate Using Interactive Video Games in Treating Adults with Amblyopia

    Rochester, MN

  4. Exparel Injection for Postoperative Orbital Pain

    Rochester, MN

  5. Glaucoma Biomarkers

    Rochester, MN

  6. A Study of the Effects of Pneumatic Vitreolysis on Vitreomacular Traction

    Rochester, MN

  7. A Study to Evaluate the Use of Nivolumab and Pomalidomide Combination for Relapsed/Refractory Primary Central Nervous System Lymphoma and Primary Vitreoretinal Lymphoma

    Jacksonville, FL, Rochester, MN

  8. A Study to Assess Screening for Diabetic Retinopathy Using Retinal Camera in Family Medicine Clinic

    Jacksonville, FL

  9. Intraocular Pressure in Ocular Hypertensives with Scleral Lens Wear

    Rochester, MN

  10. A Study to Evaluate the Safety and Effectiveness of Intratumoral and Intravenous Injection of Vesicular Stomatitis Virus Expressing Human Interferon Beta, and Tyrosinase Related Protein 1 (VSV-IFNb-TYRP1) in Patients with Metastatic Ocular Melanoma and Previously Treated Patients with Unresectable Stage III/IV Cutaneous Melanoma

    Jacksonville, FL, Rochester, MN

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