Filter Results

Clinical Studies

Open

  • AuTophagy Activation for Cardiomyopathy Due to Anthracycline tReatment (ATACAR) Trial Rochester, Minn.

    The purpose of this study is to evaluate the additional benefit of pravastatin and spironolactone when given in combination with carvedilol and lisinopril versus carvedilol and lisinopril alone.

     

  • Biomarkers to Predict Cancer Therapy-related Cardiotoxicity Jacksonville, Fla.

    The primary purpose of this study is to collect Biospecimens from patients who developed chemotherapy related cardiac toxicity (CRCT) and patients who are at a high risk for developing CRCT identified prior to the onset of therapy.

  • CAncer Survivor CArdiomyopathy DEtection (CASCADE) Pilot Study (CASCADE) Rochester, Minn.

    The purpose of this study is to improve the cardiovascular care of adult cancer survivors by contributing much-needed evidence regarding optimal surveillance and treatment recommendations. This application’s objective is to obtain the data necessary to plan an adequately powered randomized clinical trial (RCT) across a nation-wide network that will define prospectively the clinical and economic efficacy of a screening program that uses AI-ECG and/or NT-pro-BNP in an at-risk adult cancer survivor population.

  • Cardio-Oncology Clinic Registry Rochester, Minn.

    The purpose of this study is to establish a retrospective and prospective clinical registry of patients seen in the cardio-oncology clinic to characterize trends in the composition and outcomes of the population seen in the clinic, as well as initial clinical analyses on cardiovascular toxicities.

  • Home Telemonitoring In Patients after Myocardial Infarction, HELP ME trial (HELP ME) Rochester, Minn.

    The purpose of this study is to evaluate patients undergoing cardiac catheterization. The hypothesis is that patients who go home with 12 lead ECG home telemonitoring will have decreased general and cardiac ED presentation and hospital readmission rates without an increase in major adverse cardiac events and at a lower health care utilization cost compared to patients with standard therapy alone.

  • TrAstuzumab Cardiomyopathy Therapeutic Intervention with Carvedilol (TACTIC) Trial (TACTIC) Rochester, Minn., Jacksonville, Fla.

    The purpose of this study is to evaluate different strategies of cardiovascular therapy with Carvedilol, aiming to reduce the incidence of left ventricular ejection fraction (LVEF) decline and heart failure (HF) in patients undergoing curative intent Trastuzumab for breast cancer.

     

    .

Contact Us for the Latest Status

Closed for Enrollment

  • Angiogram Based Fractional Flow Reserve FFRangio - A Validation Study Rochester, Minn.

    In the present study we aim at validating the computation of FFRangio values from the angiogram by comparing them to measured wire-based FFR values, in a larger scale and in a completely blinded manner. Investigation of a wide range of users in various conditions may strengthen the reliability of the FFRAngio measurements.

  • Brain Natriuretic Peptide Evaluation for the Avoidance of Treatment-Related Heart Failure (BEAT-HF) Trial in Breast Cancer Survivors Pre-Study Rochester, Minn.

    The purpose of this study is to determine if Brain Natriuretic Peptide (NT-pro-BNP) values increase over time in breast cancer survivors and correlate with cardiac dysfunction. This study will define the average NT-pro-B-natriuretic peptide values in female breast cancer patients 1, 2, 3, 4, and 5 years out from anthracycline-based chemotherapy.

  • Evaluation of Shared Decision Making in Cardio-Oncology Rochester, Minn.

    The purpose of this study is to explore, through surveys of providers and patients, the frequency and nature of shared decision making aspects in the cardiovascular care of cancer patients seen in the cardio-oncology clinic referred by an oncology provider.

     

     

  • Prediction and Early Detection of Cardiotoxicity in Women with Breast Cancer Undergoing Chemotherapy Revised Rochester, Minn.

    The purpose of this study is to collect and correlate the data from various cardiovascular risk asessments to successfully measure the risk of heart toxicity in patients receiving chemotherapy for breast cancer.

  • The Impact of Short- and Long-term Endothelial Function Assessment by Peripheral Arterial Tonometry (PAT) on Clinical Outcome in Subjects Admitted to Chest Pain Unit (CPU) Rochester, Minn.

    It is recognized that endothelial dysfunction is a major factor contributing to the atherogenic process. Abnormal function of the endothelium is detectable prior to obvious intimal lesions in patients with risk factors for atherosclerosis. Endothelial dysfunction is a systemic disorder and a key variable in the pathogenesis of atherosclerosis and its complications. Measurement of peripheral vasodilator response with fingertip peripheral arterial tonometry (PAT) technology (EndoPAT; Itamar Medical, Caesarea, Israel) is emerging as a useful method for assessing vascular function. EndoPAT may be a potential valid test increasing the accuracy, sensitivity and specificity for detection of subjects to chest pain unit (CPU) with chest pain but no obvious coronary artery disease (CAD). This is a relatively fast non-invasive bedside test, relatively low-cost and has no side effects. Therefore, the primary objective of the study is to test the hypothesis that abnormal endothelial function as assessed by EndoPAT testing will increase the prediction of the short (in-hospital) and long-term (1-year) outcome of patients presenting to the chest pain unit.

  • TrAstuzumab Cardiomyopathy Therapeutic Intervention with Carvedilol (TACTIC) Trial Rochester, Minn.

    The purpose of this study is to evaluate different strategies of cardiovascular therapy with carvedilol aiming to reduce the incidence of heart function declines and heart failure in at-risk breast cancer patients while on trastuzumab therapy.

.