Tab Title Description
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
NCT ID: NCT04190433
Sponsor Protocol Number: MC2014
About this study
The purpose of this study is to evaluate the additional benefit of pravastatin and spironolactone when given in combination with carvedilol and lisinopril versus carvedilol and lisinopril alone.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
- ≥ 18 years of age.
- New diagnosis of reduced cardiac function.
- Within 12 months of anthracycline-based cancer therapy for hematological malignancy, breast cancer, or sarcoma
- History of HF of any class and type, or diagnosis of cardiomyopathy prior to anthracycline therapy.
- On active therapy with a fibrate, niacin, or eplerenone.
- History of myopathy/rhabdomyolysis.
- History of statin intolerance.
- Active treatment for hyperlipidemia.
- History of gout.
- Active treatment for liver disease.
- Unexplained persistent elevations of serum transaminases (above upper limit of normal over two weeks).
- Addison disease.
- eGFR < 30 mL/minute/1.73 m^2.
Publications are currently not available