Clinical Trials

The purpose of this study is to determine the best noninvasive imaging exam for the diagnosis and follow-up of spontaneous coronary artery dissection, by comparing an MR angiogram, to the clinical standard CT angiogram.

This proposal aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

The purpose of this research is to compare sympathetic function (flight or fight system), arterial structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

The sympathetic function across the menstrual cycle in premenopausal women with a history of SCAD will also be compared to age-matched premenopausal women. 

The purpose of this study is to determine differences in clinical and imaging presentation, in-hospital management and prognosis in peri-partum and non-peri-partum SCAD patients.

The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause spontaneous coronary artery dissection (SCAD), in other words, spontaneous tears in blood vessels that supply the heart.

Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person.

The primary goal of this project is to describe the clinical and physiologic characteristics of Spontaneous Coronary Artery Dissections (SCAD) in order to increase awareness, understanding, treatment and prevention of a potentially fatal cardiovascular event.

This study will be a retrospective and prospective review of medical course and current health of men and women with SCAD.

The purpose of this study is to screen for unique or characteristic circulating peptides, hormonal biomarkers and circulating mRNA in patients who have experienced spontaneous coronary artery dissection (SCAD).

Spontaneous coronary artery dissection (SCAD) is uncommon but important cause of acute coronary syndrome and sudden cardiac death. There is very little data exists in regards to patient clinical characteristics, risk factors, treatment and outcomes. Our objective is to prospectively assess long term outcomes. 

The purpose of this study is to perform and analyze standard transthoracic echocardiography with contrast and strain imaging in 80 consecutive patients seen in the Mayo Clinic Spontaneous Coronary Artery Dissection (SCAD) Clinic and interpret any prior pre- or post-SCAD echocardiogram studies for comparison.

The researchers are trying to see whether contrast-enhanced ultrasonography, shear wave elastography, strain imaging, and 3-D volume ultrasonography improves arterial wall visualization and identifies arterial elastic properties among individuals with fibromuscular dysplasia (FMD), atherosclerosis, personal history of spontaneous coronary artery dissections (SCAD), or personal history of segmental arterial mediolysis (SAM) that may be different compared to those without the aforementioned conditions.

The purpose of this study is to identify and characterize heart rhythm disorders including atrial arrhythmias such as atrial fibrillation, ventricular arrhythmias such as ventricular tachycardia, conduction abnormalities, etc. among patients with spontaneous coronary artery dissection (SCAD).