Displaying 22 studies

  • The Mayo Clinic Registry of Midlife Women Scottsdale/Phoenix, AZ; Eau Claire, WI; Jacksonville, FL; Rochester, MN

    The purpose of this study is to establish a data repository of peri- and postmenopausal women receiving primary care at Mayo clinic sites.  This collection of data will be from retrospective review of medical records along with prospective surveys completed by subjects.

  • Ovarian Axis Hormones and Adrenal Androgens and Measurements of Satiation, Postprandial Satiety, and Hunger in Pre- and Post-menopausal Women Rochester, MN

    The purpose of this study is to determine the correlation between ovarian axis hormones and adrenal androgens and changes in satiation, postprandial satiety, and hunger in pre- and post-menopausal women. Since differential hormone profile is considered an important underlying physiologic change through the menopausal transition, changes in ovarian sexual hormones and adrenal androgen levels may have an association with changes in satiation, postprandial satiety, and hunger.

  • Impact of Endogenous E2 on SSI and GH Rebound Rochester, MN

    Endogenous estrogens maintain growth hormone (GH) secretion in postmenopausal women by potentiating endogenous GH-releasing hormone (GHRH) drive and restraining somatostatin inhibition of GH release.

  • A Study to Assess Reproductive History in Kidney Donors Scottsdale/Phoenix, AZ; Rochester, MN

    The purpose of this study is to analyze the effect of parity, menopause and reproductive lifespan on kidney structure and function.

  • A Study to Assess Adrenal Aging in Menopausal Women Rochester, MN

    The purpose of this study is to determine the effect of bilateral salpingo-oophorectomy (BSO) on adrenal aging as measured by the 24h urine steroid metabolome and as compared to the age-matched postmenopausal women.  


  • Testing of a Menopause Management Digital Health Application Scottsdale/Phoenix, AZ; Eau Claire, WI; Jacksonville, FL; Rochester, MN

    The purpose of this study is to test a digital health tool developed collaboratively by Mayo Clinic inverstigators and a digital health company to improve the meopause experience of midlife women.

  • A Study of How the Regulation of Resting Blood Pressure is Altered in Menopausal Women Rochester, MN

    The purpose of this study is to investigate whether the autonomic support of blood pressure alters after menopause in women, the importance of female sex hormones in blood pressure control, and the potential for exercise training to provide a therapeutic pathway that might limit increases in blood pressure in this population.

  • A Study to Evaluate Sleep in Women with Surgically-induced Premature Menopause Rochester, MN

    Amongst the different aging female phenotypes, women exposed to premature menopause due to bilateral salpingo-oophorectomy (BSO) at premenopausal age exhibit greater risk of adverse outcomes compared to controls without BSO. The abrupt ovarian hormones loss caused by BSO precipitates menopause-associated health risks, including increasing risk of cognitive decline and Alzheimer’s disease (AD). Emerging literature from epidemiological and experimental studies suggests that sleep disruption may be a significant contributor to cognitive decline and neurodegeneration. It is well-known that sleep disturbances increase dramatically during menopause transition. However, as these data have been gathered primarily from women undergoing natural menopause, it is unclear ...

  • Histology of Functional Density in Postmenopausal Breast Rochester, MN

    Increased mammographic density is recognized as an important risk factor for developing breast cancer, however, the underlying mechanism explaining this relationship is unclear. The investigators hypothesize that Molecular Breast Imaging (MBI) can more accurately distinguish dense tissue on mammography which is at high risk from dense tissue at low risk by indicating cellular activity in dense tissue as radiotracer uptake (functional density) in the breast. In this pilot study, the investigators want to compare the histological characteristics of breast tissue in patients with who have similar density on mammography but different levels of functional density on MBI.

  • A Study to Learn More About the Discussions Between Patients and Clinicians of Symptomatic Treatment Options for Menopause Jacksonville, FL

    The purpose of this study is to understand how and what patients and clinicians discuss and think about treatment options for menopausal symptoms.

  • A Study to Evaluate the Impact of Menopause on Cardiac Stiffness Acquired with Magnetic Resonance Elastography Rochester, MN

    The purpose of this study is to evaluate the effects of menopause transition on myocardial stiffness in healthy female subjects without a history of heart disease who are expected to be close to the average age of menopause transition (~51 years), in the 48-53 year age range. All eligible subjects will undergo two study visits that will include a cardiac MRI/MRE exam, echocardiography imaging and blood test.

    The purpose of this aim is to characterize the relationship between the serum estradiol level and myocardial stiffness changes in young women (<46) on estradiol replacement therapy after bilateral oophorectomy.  Subjects will be ...

  • A Study of the Efficacy of Lorcaserin for Weight Loss in Overweight Peri- and Postmenopausal Women Rochester, MN

    The purpose of this study is to obtain preliminary evidence regarding the efficacy of lorcaserin for weight loss in overweight peri- and postmenopausal women who are also experiencing menopause-related vasomotor symptoms.

  • Fulvestrant and/or Anastrozole in Treating Postmenopausal Patients With Stage II-III Breast Cancer Undergoing Surgery Scottsdale/Phoenix, AZ; Rochester, MN

    This randomized phase III trial has several primary objectives. One primary objective is to compare the efficacy of 3 different endocrine therapies, the estrogen receptor down regulator fulvestrant and the aromatase inhibitor anastrozole, either alone or in combination, in reducing cancer growth before surgery (neoadjuvant) in postmenopausal women with clinical stage II-III estrogen receptor positive and HER2 negative breast cancer. Another primary objective is to evaluate whether patients who achieved a modified PEPI (Preoperative Endocrine Prognostic Index) score of 0, defined by tumor size <5 cm,="" n0,=""><2.7% (by central testing), at surgery post 6 months of neoadjuvant endocrine therapy ... (by="" central="" testing),="" at="" surgery="" post="" 6="" months="" of="" neoadjuvant="" endocrine="" therapy="" ...="">

  • A Study to Evaluate Patient Perspectives of Vaginal Bleeding During the Menopause Transition and Future Innovations Addressing Changes in Vaginal Bleeding Patterns Jacksonville, FL

    The primary purpose of this study is to assess how women within different stages of menopause perceive menstrual bleeding changes during the menopause transition within the outpatient gynecology practice.

  • Hot Flashes and Neurovascular Function in Women Rochester, MN

    The purpose of this study is to to better understand the relationship between autonomic neurovascular function and hot flashes associated with menopause.

  • Study of Letrozole With or Without BYL719 or Buparlisib, for the Neoadjuvant Treatment of Postmenopausal Women Rochester, MN

    The purpose of the study is to determine whether treatment with a PI3K inhibitor plus letrozole leads to an increase in pathologic clinical response and Objective Response Rate compared to treatment with placebo plus letrozole in patients with Breast cancer

  • Microvascular Function and Exercise Training in Postmenopausal Women Rochester, MN

    Blood pressure rises in postmenopausal (PM) women and may be caused by widespread microvascular vasodilator dysfunction in conjunction with increased efferent sympathetic vasoconstrictor nerve activity. The goal of this study is to measure the effects of regular physical activity on vasodilator effects of acute administration of estrogen in postmenopausal women.

  • A Study to Evaluate S-Adenosyl-L-Methionine for the Treatment of Hot Flashes Rochester, MN

    The purpose of this study is to assess the side effects and effectiveness of s-adenosyl-L-methionine for treating hot flashes in women who have a history of breast cancer or who do not wish to take estrogen due to a perceived increased risk of breast cancer.

  • A Study to Evaluate the Impact of Menopause on Blood Pressure Regulation During Exercise Rochester, MN

    The purpose of this study is to determine how menopause influences blood pressure responses during exercise in women.

  • Letrozole in Treating Postmenopausal Women with Ductal Carcinoma in Situ Rochester, MN

    RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by blocking the use of estrogen by the tumor cells or by lowering the amount of estrogen the body makes.

    PURPOSE: This phase II trial is studying how well letrozole works in treating women with ductal carcinoma in situ.

  • Investigating Magnesium Glycinate in Structure/Function Role of Hot Flashes. Jacksonville, FL

    The goal of this study is to further evaluate the effect of magnesium on the symptoms of menopause, specifically vasomotor symptoms (VMS) in breast cancer patients and/or women at an elevated risk of breast cancer.

  • Oxybutynin Chloride in Managing Hot Flashes Rochester, MN

    This randomized phase III trial studies how well oxybutynin chloride works in managing hot flashes in patients who are not candidates for, or not interested in hormone replacement therapy. Previous studies have shown that oxybutynin is effective in managing hot flashes, however doses used in prior studies have resulted in side effects. This trial is evaluating lower doses of oxybutynin with the goal of determining if they are efficacious with less side effects.


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