A Study of How the Regulation of Resting Blood Pressure is Altered in Menopausal Women


About this study

The purpose of this study is to investigate whether the autonomic support of blood pressure alters after menopause in women, the importance of female sex hormones in blood pressure control, and the potential for exercise training to provide a therapeutic pathway that might limit increases in blood pressure in this population.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria: 

  • All women will have a systolic blood pressure lower than 150 mmHg and a diastolic blood pressure lower than 95 mmHg
  • Subjects will also be non-obese (BMI <30), non-smokers, non-diabetic, and if on blood pressure medication they will be monotherapy taking one type of anti-hypertensive medications. 
  • Participants will be asked to stop taking the medication 5 half-lives before the study day (this will range from 2-5 days depending on the type of medication).

Group 1:

  • Healthy, young women 
  • Ages of 18 and 35 yrs 

Group 2:

  • Postmenopausal women 
  • 45-75 years of age with no history of menopausal hormone therapy 
    • Menopause will be defined as amenorrhea for >12 months excluding oophorectomy
    • Participants will be limited to women not taking hormone replacement therapy. 

Group 3:

  • Postmenopausal women 
  • 45-75 years of age on transdermal estrogen

Exclusion Criteria:

  • Subjects taking any other medications, except for oral contraceptives or hormone therapy, will not be eligible
  • Candidates will be considered ineligible if they have any acute or chronic disorders (other than mild hypertension, where systolic blood pressure is 140 to 150 mmHg)



Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Closed for enrollment

More information


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