A Study of How the Regulation of Resting Blood Pressure is Altered in Menopausal Women


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 09-008584
    Sponsor Protocol Number: 09-008584

About this study

The purpose of this study is to investigate whether the autonomic support of blood pressure alters after menopause in women, the importance of female sex hormones in blood pressure control, and the potential for exercise training to provide a therapeutic pathway that might limit increases in blood pressure in this population.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria: 

  • All women will have a systolic blood pressure lower than 150 mmHg and a diastolic blood pressure lower than 95 mmHg
  • Subjects will also be non-obese (BMI <30), non-smokers, non-diabetic, and if on blood pressure medication they will be monotherapy taking one type of anti-hypertensive medications. 
  • Participants will be asked to stop taking the medication 5 half-lives before the study day (this will range from 2-5 days depending on the type of medication).

Group 1:

  • Healthy, young women 
  • Ages of 18 and 35 yrs 

Group 2:

  • Postmenopausal women 
  • 45-75 years of age with no history of menopausal hormone therapy 
    • Menopause will be defined as amenorrhea for >12 months excluding oophorectomy
    • Participants will be limited to women not taking hormone replacement therapy. 

Group 3:

  • Postmenopausal women 
  • 45-75 years of age on transdermal estrogen

Exclusion Criteria:

  • Subjects taking any other medications, except for oral contraceptives or hormone therapy, will not be eligible
  • Candidates will be considered ineligible if they have any acute or chronic disorders (other than mild hypertension, where systolic blood pressure is 140 to 150 mmHg)



Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Closed for enrollment


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