Phenotyping and genetic interrogation of microglia in Alzheimer's disease models

Dr. Ikezu has made significant contributions to the classification of the activation phenotype of microglia. These studies identified miR-155, APOE and TREM2 as key molecules for shaping neurodegenerative microglia, which also are genetically associated with Alzheimer's disease. This work is reframing the biology of microglia and its disease implications.

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