Systems Biology and Biomarker Panels

In this research project, our lab is applying systems biology techniques to understand disease mechanisms and develop biomarker panels for neurodegenerative diseases.

Our research team is exploring the application of multiple systems biology approaches to establish signatures of disease conditions in Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, metabolic disorders and aging. These approaches include proteomics, transcriptomics, epigenetics and metabolomics. The signatures we establish will be useful for improving the understanding of disease mechanisms and for diagnosis, prognosis and monitoring of therapeutic effectiveness.

Our team worked with the Metabolomics Core to demonstrate that application of metabolomics could detect early changes. These changes were associated with altered energy use, mitochondrial function and energetic stress in blood, cerebrospinal fluid and fibroblasts from patients with mild cognitive impairment and Alzheimer's disease and in multiple mouse models of Alzheimer's disease.