The research laboratory of Andrew D. Badley, M.D., focuses on translating clinical observations by performing basic science experiments in order to understand the mechanistic basis underlying those observations.

This approach has led the laboratory in many varied and unpredicted directions, including describing two novel molecules:

  • TNF-related apoptosis-inducing ligand (TRAIL)-short, an antagonistic TRAIL splice variant
  • Casp8p41, a fragment of caspase-8 that is produced through the action of HIV protease