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This pancreatic tumor cell shows the actin cytoskeleton (red) and the epidermal growth factor receptor (EGFR) (green) internalizing excess growth factor receptors, which contribute to unchecked growth.
The cytoplasm (red) and nuclei (blue) of pancreatic cancer cells are invading through a porous filter in culture.
These cellular organelles — the autophagolysosome (AP-LY), the lipid droplet (LD) and the mitochondria (MITO) — are often in close proximity to each other and work synergistically.
Hepatocytes cultured from rats fed a control diet (left) have far fewer lipid droplets (red) than hepatocytes cultured from rats fed a diet containing alcohol for six weeks (right). DNA/nucleus is in blue.
The Cytoskeletal Membrane Dynamics Lab has three main focus research areas, encompassing tumor cell growth and migration, metabolism of lipids by the liver, and liver disease caused by alcoholism.
Dr. McNiven leads a talented research team dedicated to understanding basic processes performed by cells of the pancreas and liver altered during disease.
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