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This pancreatic tumor cell shows the actin cytoskeleton (red) and the epidermal growth factor receptor (EGFR) (green) internalizing excess growth factor receptors, which contribute to unchecked growth.
The cytoplasm (red) and nuclei (blue) of pancreatic cancer cells are invading through a porous filter in culture.
These cellular organelles — the autophagolysosome (AP-LY), the lipid droplet (LD) and the mitochondria (MITO) are often in close proximity to each other and work synergistically.
Hepatocytes cultured from rats fed a control diet (left) have far fewer lipid droplets (red) than hepatocytes cultured from rats fed a diet containing alcohol for six weeks (right). DNA/nucleus is in blue.
The Cytoskeletal Membrane Dynamics Lab studies membrane and cytoskeletal interactions that play a key role in essential processes performed by cells of the pancreas and liver such as secretion, endocytosis, migration and metabolism.
Driven by the need to better understand the origins of pancreatic and liver cancer, the Cytoskeletal Membrane Dynamics Lab studies tumor cell growth, lipid metabolism and liver disease.
Dr. McNiven has published extensive research on cellular mechanisms that cause pancreatic and liver cancer metastasis.
Contact Dr. McNiven about his research or for information about training, fellowships and careers in the Cytoskeletal Membrane Dynamics Lab at Mayo Clinic.
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