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Laboratories

Cytoskeletal Membrane Dynamics: Mark A. McNiven

  • About
    • About
    • About the Lab
    • Research Team
  • Focus Areas
    • Focus Areas
    • Tumor Cell Growth and Migration
    • Lipid Droplet Biology and Fatty Liver
    • Alcohol-Induced Liver Damage
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  • Defining the cellular mechanisms of liver and pancreatic cancer and metabolic disease

    This pancreatic tumor cell shows the actin cytoskeleton (red) and the epidermal growth factor receptor (EGFR) (green) internalizing excess growth factor receptors, which contribute to unchecked growth.

  • Pancreatic tumor cells grow and invade during metastasis

    The cytoplasm (red) and nuclei (blue) of pancreatic cancer cells are invading through a porous filter in culture.

  • Cellular organelles essential to regulation of hepatocyte fat metabolism

    These cellular organelles — the autophagolysosome (AP-LY), the lipid droplet (LD) and the mitochondria (MITO) are often in close proximity to each other and work synergistically.

  • The cellular basis of fatty liver disease: Hepatocytes accumulate lipid droplets when exposed to alcohol

    Hepatocytes cultured from rats fed a control diet (left) have far fewer lipid droplets (red) than hepatocytes cultured from rats fed a diet containing alcohol for six weeks (right). DNA/nucleus is in blue.

About

The Cytoskeletal Membrane Dynamics Lab studies membrane and cytoskeletal interactions that play a key role in essential processes performed by cells of the pancreas and liver such as secretion, endocytosis, migration and metabolism.

About

Focus Areas

Driven by the need to better understand the origins of pancreatic and liver cancer, the Cytoskeletal Membrane Dynamics Lab studies tumor cell growth, lipid metabolism and liver disease.

Focus areas

Publications

Dr. McNiven has published extensive research on cellular mechanisms that cause pancreatic and liver cancer metastasis.

Publications

Contact

Contact Dr. McNiven about his research or for information about training, fellowships and careers in the Cytoskeletal Membrane Dynamics Lab at Mayo Clinic.

Contact
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ORG-00111574

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