Targeting mechanisms of cellular damage to promote tissue regeneration
The Bone Injury and Repair Laboratory led by Abhishek Chandra, Ph.D., studies mechanisms underlying tissue deterioration and potential ways to promote tissue regeneration during physiological and pathological osteoporosis. Dr. Chandra's lab is identifying novel pathways and exploring sustainable treatment options for osteoporosis by targeting cellular processes.
The Bone Injury and Repair Laboratory led by Abhishek Chandra, Ph.D., studies mechanisms underlying tissue regeneration so as to find therapeutic options for physiological and pathological osteoporosis.
The research of Dr. Chandra focuses on the pathophysiology of bone loss due to aging, radiotherapy and several disease conditions. Dr. Chandra's work also focuses on understanding the mechanism of fate commitment of mesenchymal lineage cells during pathological conditions and the resulting bone marrow environment.
Dr. Chandra is particularly interested in providing therapeutic options for radiotherapy-induced osteoporosis and resulting fractures to improve bone quality. In addition, Dr. Chandra focuses on DNA damage and repair, cellular apoptosis and senescence pathways involved in bone cells, and on how the regulation of these pathways affects bone architecture.
About Dr. Chandra
Dr. Chandra is a molecular biologist and biochemist in the Department of Physiology and Biomedical Engineering and the Division of Geriatric Medicine and Gerontology in the Department of Internal Medicine at Mayo Clinic's campus in Rochester, Minnesota. He also serves as an assistant professor of physiology in Mayo Clinic College of Medicine and Science. The focus of his research is aging and disease-associated bone loss, specifically reversing radiation damage to bones.