Targeting mechanisms of cellular damage to promote tissue regeneration
Abhishek Chandra, Ph.D., M.S., and his team at Mayo Clinic are exploring new treatment options for osteoporosis that target processes occurring within cells.
Overview
Mayo Clinic's Bone Injury and Repair Laboratory led by Abhishek Chandra, Ph.D., M.S., studies the causes of bone tissue deterioration and potential ways to promote tissue growth to treat osteoporosis.
Dr. Chandra and his team focus on the underlying causes of bone loss due to aging, radiotherapy and disease. The team studies the development of mesenchymal stem cells as they transition into final cell types in a process known as cell fate determination. The team also studies how aging and health conditions affect the development of cells and the bone marrow environment.
Dr. Chandra is particularly interested in developing treatments to improve bone quality in osteoporosis and in fractures caused by radiotherapy. In addition, his lab studies:
- DNA damage and repair.
- Programmed cell death, also called apoptosis.
- Cellular senescence.
- Regulation of pathways involved in age-related deterioration of bone cells.
Affiliations
Dr. Chandra's Bone Injury and Repair Lab is affiliated with these Mayo Clinic research areas: