The main focus of the Applied Neuroradiology Laboratory of David F. Kallmes, M.D., is studying intracranial saccular aneurysms.

Open brain surgery has traditionally been used to treat these aneurysms, but in recent years endovascular therapies using platinum microcoils have widely been adopted as less invasive alternatives. While the microcoils eliminate many of the risks associated with open surgery, they often fail to result in permanent closure of the aneurysm due to growth of the aneurysm itself, as well as lack of collagen synthesis and connective tissues in the aneurysm cavity.

The lab's experimental approach is to better understand the mechanism of aneurysm growth and healing following endovascular treatment. The goal is to develop new innovations for endovascular technology that improve clinical management of cerebral aneurysms.

Dr. Kallmes' multidisciplinary research team applies a variety of molecular biological, histological, tissue engineering and computational flow dynamics radiological techniques. This includes imaging the aneurysmal changes and analyzing hemodynamic changes in the aneurysm. Overall, the aim is to better understand how aneurysms heal and which treatments are best suited to improve long-term rates of aneurysm occlusion.

The Applied Neuroradiology Laboratory is also involved in multiple clinical trials of aneurysm treatments, in addition to collaborating with medical device industries as a contract lab for preclinical testing of their devices.