Infectious Diseases Research

Below are current clinical trials.

223 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. A Study to Evaluate Diagnostic Accuracy of the Controlled Attenuation Parameter(CAP) Measured by FibroScan® in Patients Scheduled for a Liver Biopsy

   Rochester, Minn.

   We purpose of this study is to evaluate the diagnosis accuracy of the Controlled Attenuation Parameter (CAP) measured by FibroScan® (both with M and XL probes) in all patients who are undergoing liver biopsy for any liver disease.  

2. PC945 Prophylaxis Or Pre-emptive Therapy Against Pulmonary Aspergillosis In Lung Transplant Recipients

   Jacksonville, Fla.

   The purpose of this study is to evaluate the safety and tolerability of PC945 for the prevention of fungal aspergillus infections in the lung in patients who have received a lung transplant.

3. SER-109 Versus Placebo To Prevent Recurrent Clostridium Difficile Infection (RCDI)

   Rochester, Minn.

   The study will involve administering the study drug as a single dose of study drug or placebo. This study is designed to demonstrate the superiority of the experimental drug versus placebo in adult patients with recurrent CDI.

4. Efficacy And Safety Of Maribavir In Transplant Recipients With Cytomegalovirus (CMV) Infections That Are Refractory Or Resistant To Treatment

   Rochester, Minn.

   The purpose of this study is to determine if an investigational treatment (Maribavir) is safe and effective in treating transplant recipient patients with cytomegalovirus (CMV) infections that are refractory or resistant to treatment.

5. A Study To Evaluate MesilatE For Treating Hospitalized Patients With COVID-19 (Enrolling By Invitation Only)

   Scottsdale/Phoenix, Ariz., Jacksonville, Fla.

   The primary purpose of this study is to determine if the reduction in TMPRSS2 activity via direct inhibition with Camostat mesilate combined with standard of care (SOC) treatment will increase the proportion of patients alive and free from respiratory failure at Day 28 in SARS-CoV-2 as compared to SOC treatment with placebo.

    

    

6. Efficacy And Safety Of COVID-19 Vaccine In Cancer Patients

   Jacksonville, Fla.

   We hypothesize that cancer patients on cytotoxic chemotherapy which affect immune response may not mount adequate immune response to COVID-19 vaccines.

   Aims, purpose, or objectives:

   1. To determine the antibody response to COVID-19 vaccine after vaccination.
   2. To assess the adverse events of COVID-19 vaccines in cancer patients.
   3. To determine the incidence and severity of COVID-19 infection after the vaccination.

7. HBRN: Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B

   Rochester, Minn.

   This is an ancillary to the NIDDK-sponsored Hepatitis B Research Network (HBRN) Study Cohort Study NCT01263587. This study will examine the balance between immune regulatory and effector responses in hepatitis B-infected participants enrolled in the HBRN study (NCT01263587).

8. Acknowledging diSParities In pRegnancy carE during COVID-19

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to assess the experience of low income pregnant women at an inner-city health system with seeking and receiving care. 

   Significant disparities in health care and birth outcomes are seen in the US during normal times. During COVID-19, limited access to health care resources, social distancing and stay at home orders, and shortages of food and other necessities may exacerbate these disparities. 

9. A Study to Assess Steroid Dosing by bioMARker Guided Titration in Critically Ill Patients With Pneumonia

   Rochester, Minn.

   The purpose of this study is to compare a standard steroid dosing algorithm to a novel biomarker-tailored steroid dosing algorithm for patients receiving corticosteroids for community acquired pneumonia.  Patients with severe community acquired pneumonia may benefit from adjunctive corticosteroid therapy. The optimal patient selection, dosing and duration of steroids is unknown.

10. A Study to Evaluate the Pandemic Response Optimizing Technology and Ethics for Coronavirus Teams Implementing Novel Genetics

    Rochester, Minn.

    The purpose of this study is to explore lay understandings toward participating in and perceptions of consent to biospecimen research and valuation of genetics in SARS-COV-2 infection, testing, immunity, and vaccine development, to explore professional attitudes toward and perception of barriers and facilitators for implementating genetic technology to facilitate understanding of SARS-COV-2 infection and immunity, improvement and scale-up of testing, and vaccine development, and to identify ethical, social, and inter-professional aspects of microbial genetic technology implementation in population health surveillance, clinical test development, and vaccine research.We hypothesize that engagement with individuals whom directly experience and/or are impacted by the increasing use of SARS-Cov-2 genetic technology, including COVID-19 Pandemic Response Biobank contributors and interdisciplinary expert teams will help identify ethical and social issues in adopting and implementing emerging technology.