Voice Signal PASC Study


About this study

The purpose of this study is to remotely use the Ellipsis Health (EH) voice analysis technology to record the speech patterns and content of individuals with a recent diagnosis of Coronavirus-19 (COVID-19) presenting to the post-COVID-19 clinic at Mayo Clinic, to validate its use as a tool to screen for major depressive disorder (MDD) and generalized anxiety disorder (GAD) against gold-standard questionnaires used in clinical practice namely the PHQ-9 and GAD-7

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Aged 18 years of age or older.
  • Patients who have had a recent episode of COVID-19 who present to the post COVID-19 clinic.
  • Access to smartphone (iOS or Android operating systems).
  • Ability to complete study questionnaires and provide voice samples using a smartphone application.

Exclusion Criteria:

  • Known history of voice disorder either primary or secondary to neuromuscular or other pathology.
  • Cognitively impaired patients.
  • Unstable cardiovascular or pulmonary diseases.
  • History of seizures.

Eligibility last updated 10/7/21. Questions regarding updates should be directed to the study team contact.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ryan Hurt, M.D., Ph.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Obediah Bauer

(507) 284-3261


More information


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