Infectious Diseases Research

Below are current clinical trials.

273 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. Dental Prophylaxis for the Prevention of Infective Endocarditis

   Rochester, Minn.

   The purpose of this study is to determine the percentage of patients at moderate risk for infective endocarditis (IE) who are receiving antibiotic prophylaxis post-2007 in Olmsted County, Minnesota.

2. Detection of Infection in Arthroplasty

   Rochester, Minn.

   The purpose of this study is to determine the sensitivity, specificity, positive and negative predictive values of molecular detection of microorganisms, detection of microbial proteins and antibodies against microorganisms, and inflammatory markers (e.g., leukocyte esterase, CRP) in synovial fluid for the diagnosis of prosthetic joint infection (PJI).

3. Communities During COVID – Focus Groups

   Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The study seeks to understand the impacts the COVID pandemic has brought to the communities, how communities are coping and how we can build resilience to prepare future health crises.

4. COVFIS-HOME: COVID-19 Pilot Study of Fisetin to Alleviate Dysfunction and Decrease Complications

   Rochester, Minn.

   The purpose of this study is to determine whether short-term treatment with Fisetin reduces the rate of death and long term complications related to COVID-19.

5. Echocardiographic Imaging in Management of Staphylococcus aureus bacteremia

   Rochester, Minn.

   Staphylococcus aureus is responsible for at least 20% of the healthcare associated blood stream infections in the United States. One of the most worrisome complications of S. aureus bacteremia (SAB) is infective endocarditis (IE).Our goal from this project is to prospectively validate the Predicting Risk of Endocarditis Using a Clinical Tool (PREDICT) scoring system and to assess the potential novel risk factors to optimize the PREDICT scoring system prior to formal implementation in clinical practice.

6. Hepatitis C Therapeutic Registry and Research Network

   Scottsdale/Phoenix, Ariz.

   The primary purpose of the HCV-TARGET study is to establish a nationwide registry of patients undergoing treatment with antiviral therapies for chronic hepatitis C (HCV) at both academic and community practices.

7. Healthy Immigrant Families: Working Together To Move More and To Eat Well

   Rochester, Minn.

   This project will broadly explore the efficacy of community participation in the design and implementation of an intervention to improve physical activity and nutrition among immigrant and refugee (Hispanic, Somali, Sudanese, Cambodian) families in Rochester, Minnesota

8. Sofosbuvir/GS-5816 Fixed-Dose Combination in Adults with Chronic HCV Infection and Child-Pugh Class B Cirrhosis

   Scottsdale/Phoenix, Ariz.

   This study will evaluate the efficacy, safety, and tolerability of sofosbuvir (SOF)/GS-5816 fixed dose combination (FDC) with and without ribavirin (RBV) for 12 weeks and SOF/GS-5816 FDC for 24 weeks in adults with hepatitis C virus (HCV) infection and Child-Pugh (CPT) class B cirrhosis.

9. Gilead Sustained Virologic Response (SVR) Registry

   Jacksonville, Fla.

   This Registry is designed to provide long term clinical and virologic follow up in subjects who have achieved sustained virologic response (SVR) while participating in a previous Gilead sponsored Hepatitis C Virus (HCV) study. This long term follow up study is observational and no treatment is provided for HCV.

10. A Study to Evaluate Entolimod on Immune System Aging in Healthy Geriatric Subjects Receiving Influenza Vaccination

    Rochester, Minn.

    The purpose of this study is to measure changes of the anti- A/H1N1, anti-A/H3N2, and anti-B influenza virus strains serum circulating antibodies (as assessed using hemagglutination inhibition (HAI) assay) levels in elderly patients.