Infectious Diseases Research

Below are current clinical trials.

223 studies in Infectious Diseases Research
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. A Study Using VE303 To Prevent Recurrence Of Clostridium Difficile Infection

   Rochester, Minn.

   The purpose of this study will evaluate the safety and effectiveness of VE303 for participants with recurrent Clostridium difficile infection (rCDI).

2. Epigenomic Biomarkers of HIV-Associated Hepatocellular Cancer in Nigeria

   Rochester, Minn.

   The main objective of this study is to identify minimally invasive, blood-based methylomic markers by comparing blood cfDNA methylation patterns among HIV-infected and uninfected HCC patients, and in HIV-infected but HCC-free patients. 
    

3. A Study Evaluating The Safety And Effectiveness Of Anti-Influenza Intravenous Hyperimmune Immunoglobulin (IVIG) For Adults Hospitalized With Influenza

   Rochester, Minn.

   Influenza (the flu) is a common illness that usually occurs in autumn and winter. The flu is usually mild, but can cause serious illness or death. The purpose of this study is to test the safety and effectiveness of an antibody against the flu (called intravenous hyperimmune immunoglobulin or IVIG) in people who are hospitalized for severe flu.

4. Echocardiographic Imaging in Management of Staphylococcus aureus bacteremia

   Rochester, Minn.

   Staphylococcus aureus is responsible for at least 20% of the healthcare associated blood stream infections in the United States. One of the most worrisome complications of S. aureus bacteremia (SAB) is infective endocarditis (IE).Our goal from this project is to prospectively validate the Predicting Risk of Endocarditis Using a Clinical Tool (PREDICT) scoring system and to assess the potential novel risk factors to optimize the PREDICT scoring system prior to formal implementation in clinical practice.

5. A Study for the Use of Hepatitis C Virus Seropositive Donors into Hepatitis C Seronegative Liver Transplant Recipients

   Scottsdale/Phoenix, Ariz., Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to utilize liver allografts from HCV seropositive donors into 10 HCV seronegative recipients. 

6. Dental Prophylaxis for the Prevention of Infective Endocarditis

   Rochester, Minn.

   The purpose of this study is to determine the percentage of patients at moderate risk for infective endocarditis (IE) who are receiving antibiotic prophylaxis post-2007 in Olmsted County, Minnesota.

7. COVFIS-HOME: COVID-19 Pilot Study of Fisetin to Alleviate Dysfunction and Decrease Complications

   Rochester, Minn.

   The purpose of this study is to determine whether short-term treatment with Fisetin reduces the rate of death and long term complications related to COVID-19.

8. Communities During COVID – Focus Groups

   Rochester, Minn., Jacksonville, Fla., Scottsdale/Phoenix, Ariz.

   The study seeks to understand the impacts the COVID pandemic has brought to the communities, how communities are coping and how we can build resilience to prepare future health crises.

9. A Study to Evaluate the Characteristics and Role of Mucosal Microbiome after Treatment of Clostridium-difficile Infection

   Rochester, Minn.

   The purpose of this study is to characterize the mucosal microbiome in patients who have recently been treated for Clostridium-difficile Infection (CDI) in comparison to that of control population to determine the effect of the mucosal associated microbiome on outcome of CDI.
   
    

10. A Study to Evaluate The Negative Predictive Value and Non-irritant Skin Testing Concentrations of Antibiotics

    Jacksonville, Fla.

    The purpose of this study is to accurately determine the negative predictive value of skin testing with antibiotics.