Magnetic bead-based biofluid proteomics

The Multiomics Mass Spectrometry Core is developing magnetic bead-based workflows to enrich and analyze low-abundance proteins from biofluids such as plasma, serum and cerebrospinal fluid. These methods enable reproducible, scalable and deep proteomic profiling of biofluids and extracellular vesicles.

Capabilities

Automated magnetic bead workflows on the KingFisher Apex and Opentrons Flex platforms ensure consistent and high-throughput enrichment of proteins and vesicles from large sample cohorts.

Applications

• Plasma and cerebrospinal fluid proteome profiling.
• Extracellular vesicle enrichment and analysis.
• Biomarker discovery in clinical and preclinical studies.
• Longitudinal and cross-sectional cohort studies.
• High-throughput screening of biofluid samples.

Data analysis and support

The core uses Biognosys Spectronaut software with integrated statistical, pathway and enrichment analyses to analyze proteomic data. The bioinformatics team provides consultation and custom analysis pipelines tailored to study design and goals.

Consultation services

If you are a new user of the core, a consultation with our research scientist is required before the core can accept samples for your proteomics project. This consultation ensures that the core offers you the highest quality services.

The core reserves two hours weekly for no-charge project consultations.

More information

For consultations or more information on access, training and service fees, email the core.