Full-service support
The core supports the production of human induced pluripotent stem cells, isolation and expansion of human tissue-derived adult stem cells.
Overview
The Human Model Systems Core provides researchers with access to high-quality human induced pluripotent stem cell production, expansion, validation and quality control services. The core strictly adheres to approved protocols, ensuring high-quality standards and consistency throughout the process.
Services under development include:
- Production of induced pluripotent stem cell-derived organoids and microphysiological systems.
- Scalable provision of healthy control and genetically modified induced pluripotent stem cell lines for research and test development.
- Production of human tissue-derived stem cells and organoids.
- Generation of stem cell derivatives and organoids (microphysiological systems).
Human induced pluripotent stem cells for research and test development
Fibroblasts isolated from a skin punch biopsy are reprogrammed into induced pluripotent stem cells. Then the induced pluripotent stem cells are used to generate numerous human cell types using directed differentiation, an application that produces a potentially unlimited source of cells and tissues that can be manipulated. These human cells can be combined to form 3D "organoids" that resemble the structure and function of a person's own tissue. Organoids and other microphysiological systems can be used for drug development and screening. They also can form the basis for transplant and cell replacement therapies.