Clinical Trials

The purpose of this study is to create a database to track long-term measurements of hand and thumb function, before and after reconstructive surgery, in patients who have defects they were born with or recieved through trauma. 

The goal of the study is to evaluate the change in pelvic floor symptoms with pessary use prior to reconstructive pelvic floor surgery for pelvic organ prolapse.  Additionally, we will assess the impact that preoperative pessary use has on patient self-reported preparedness for surgery.

The objective for this study is to learn more about the opioid prescribing patterns in the Division of Urogynecology (Department of Obstetrics and Gynecology) at our institution for pelvic organ prolapse surgery (both abdominal and vaginal routes) and isolated synthetic midurethral sling placements.

The purpose of this study is to:

1. Review the Mayo Clinic outcomes following lower extremity reconstruction for different indications

The primary objective of the study is to compare outcomes of patients undergoing sarcoma reconstructive surgery using fluorescence angiography with patients undergoing sarcoma reconstructive surgery without fluorescence angiograph.

The purpose of this study is to characterize the inflammatory markers of free flap reconstructive head and neck surgery in humans by analyzing specific inflammatory markers in blood samples from patients with the hope of better understanding free flap physiology in order to eventually improve patient outcomes.  

The purpose of this study is to identify and characterize the various postoperative psychosocial issues experienced by a cohort of patients receiving free tissue transfer for treatment of benign lesions of the jaws. 

The purpose of this study is to evaluate the safety and effectiveness of the Mentor MemoryGel® larger size ultra high profile breast implants for patients who are undergoing primary or revision reconstruction surgery.

This study is designed to investigate if transoral surgery with the patient in the seated position utilizing the da Vinci® Robotic Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA) will enable better visualization and expedited removal of benign and malignant tumors of the throat.

The purpose of this study is to evaluate surgical sterility, the microbiome, and infections post mastectomy with immediate/tissue expander surgery by using OR camera recording, surgical site and/or microbiome analysis.

The purpose of this study is to compare and identify different thoracic wall reconstruction methodologies. Subsequently, correlate these findings to assess overall surgical and clinical outcomes.

This phase II trial studies how well inolitazone dihydrochloride (efatutazone dihydrochloride) and paclitaxel work in treating patients with anaplastic thyroid cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment (advanced). Drugs used in chemotherapy, such as efatutazone dihydrochloride and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

This study is designed for patients with a cancer of the oropharynx (tonsils or base of tongue) caused by the HPV virus. Traditional treatment involves surgery followed by six weeks of daily radiation therapy. This study investigates a less intense radiation treatment following surgery that uses half the dose of radiation given over two weeks rather than six weeks. Patients will be randomly assigned to receive the less intense treatment versus the traditional treatment by coin flip. Patients are twice as likely to receive the less intense treatment during randomization.

The purpose of this study is to evaluate the clinical outcomes of lower intensity (mucosal tissue sparing) proton beam therapy after the surgical removal of oropharyngeal tumors in cancer patients who have a favorable level of risk.

The purpose of this study is to assess long-term functional outcomes after pollicization.

The objective of this study is the application of regenerative medicine techniques for advanced and individualized nasal reconstruction. Using pre-operative 3D facial scanning, the patient can choose the desired nose shape. The data can then be used to create patient-specific templates for both the nasal tip reconstruction mold and the skin/soft tissue reconstruction template.

The purpose of this study is to review published information, describe the surgical technique, and review the results of past cases of triceps muscle transfer secured with an endobutton for elbow flexion reconstruction in patients who have chronic brachial plexus injury. 

The purpose of this study is to measure the electromyographic (EMG) activity in adults who have been affected by a brachial plexus injury. Results from this study will aid in the design of assistive upper extremity orthotic devices.

The purpose of this study is to compare and identify different forms/regimens of chemotherapy/hormone therapy in breast cancer patients who underwent mastectomy and subsequent immediate breast reconstruction (tissue expander or direct-to-implant). Subsequently, correlate these findings to assess overall surgical and clinical outcomes.

This phase II trial studies how well radiation therapy and docetaxel work in treating patients with human papillomavirus (HPV)-related oropharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy with docetaxel my kill more tumor cells.

The purpose of this study is to determine if intensity-modulated radiotherapy (IMRT) or proton radiation therapy would result in improved local control rates and lowered toxicity compared to conventional radiotherapy. Data from retrospective studies suggest that IMRT and proton radiation therapy each resulted in promising outcomes for patients with sinonasal malignancy. No previous prospective study has been conducted to evaluate the outcome of sinonasal cancer treated with IMRT or proton radiation therapy.

The study would also assess if proton radiation therapy would result in equivalent or improved local control rate with similar or lower toxicity compared to IMRT.  It is not known if ...

This phase II trial studies how well pembrolizumab, chemotherapy, and radiation therapy work with or without surgery in treating patients with anaplastic thyroid cancer. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as docetaxel and doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving pembrolizumab, chemotherapy, and radiation therapy with or without surgery ...

This study observes the clinical efficacy of combining proton SBRT with PD-1 blockade immunotherapy in both the locoregionally recurrent and metastatic settings.

The purpose of this study is to collect skin that is clinical residue and would be otherwise discarded for research purposes with proper patient consent.