Clinical Trials

The purpose of this study is to assess the response of pediatric epilepsy patients to deep brain stimulation.  

The purpose of this post market study is to support the chronic clinical performance of the Infinity Deep Brain Stimulation (DBS) Implantable Pulse Generator (IPG), DBS leads, extensions and related system components.

The purpose of this study is to directly compare the predictability of tremor reduction between two thalamic Deep Brain Stimulation (DBS) strategies.

The purpose of this study is to test different stimulation parameter sets and evaluate patient outcomes.

The primary purpose of this study is to map the electrophysiological properties of deep brain stimulation (DBS) targets and associated areas by analyzing signals recorded for clinical purposes.  Electrophysiological properties such as spike statistics, power spectral density, spike-field coupling, and phase-amplitude coupling may be correlated to anatomic structures.  An atlas with these properties could improve DBS lead targeting.

The purpose of this study is to evaluate the effectiveness and safety of bilateral stimulation of the SCCwm using the Infinity DBS system as an adjunctive treatment of non-psychotic unipolar Major Depression Disorder (MDD) for adults who are experiencing an Major Depressive Episode (MDE) with inadequate response to 4 or more antidepressant treatments.

The purpose of this study is to learn the usefulness of near-infrared spectroscopy, a new type of scan, to monitor brain activity during deep brain stimulation for movement disorders.

The purpose of this study is to document characteristics of real-world outcomes for Boston Scientific Corporation’s commercially approved Vercise™ System for Deep Brain Stimulation (DBS) when used according to the applicable Directions for Use.

The purpose of this study is to track seizure occurrence, seizure probability, behavioral state, cognition, and mood using an implantable brain sensing and stimulation device (Medtronic RC+S Summit) coupled to an external, handheld, patient assistant device (PAD) with capability for patient interaction (patient data input). The system (RC+S & PAD) provides intracranial EEG (iEEG) sensing, electrical brain stimulation, and machine learning algorithms running on the RC+S and PAD that will be coupled with electrical brain stimulation (EBS) to prevent seizures and improve quality of life in patients with epilepsy

The purpose of this study is to evaluate the safety, and feasibility of adjuvant high frequency stimulation of the GPe using Deep Brain Stimulation.

The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation (DBS) of the dentate nucleus area for improving functional status in patients with moderate to severe residual upper-extremity motor impairment due to stroke.

The purpose of the study is to evaluate a new method of recording brain activity during surgery and to help determine the mechanism through which deep brain stimulation is helping patients.

The purpose of this study is to assess changes in patients agency before and after being implanted with DBS in adult patients who qualify and elect for Deep Brain Stimulation surgery for the treatment of Parkinson's Disease. This will be completed with the Agency Assessment Tool (AAT), which contains survey questions and self-assessments. 

The purpose of this study is to provide feasibility data for a novel method of defining patient-specific functional anatomic targets for Globus Pallidus Internus (GPi) Deep Brain Stimulation (DBS) placement.

The purpose of this study is to investigate the feasibility and safety of thalamic CL stimulation in restoring consciousness in epilepsy patients.

The purpose of this study is to demonstrate that the RNS® system is safe and effective as an adjunctive therapy in individuals age 12 through 17 with medically refractory partial onset epilepsy.

Does dual hemispheric stimulation of the subthalamic nucleus (STN) and fornix/hypothalamus potentially improve cognitive function in patients with Parkinsons disease.

The purpose of this study is to compare 7 tesla MRI data and 3D image of model deep brain stimulation target areas to the post-surgical image of actual placement at time of deep brain stimulation surgery, using standard of care 1.5 tesla MRI.

The overall purpose of this study is to evaluate the effectiveness and safety of brain stimulation techniques currently used for clinical patient care. To determine the likelihood of improvements in seizure frequency, neurological symptoms, and quality of life after treatment with brain stimulation in certain populations, as well as evaluate for any beneficial or deleterious side effects from these modalities. In addition, in instances were brain stimulation was used for diagnostic purposes such as with cortical mapping via TMS, outcomes will be compared to other results already available in the electronic medical record system (e.g., MRI).

The purpose of this study is to examine the long term effects of motor cortex stimulation related to pain control.

The purpose of this study is to assess how the overall impact of pain has changed in the patient's life since deep brain stimulation surgery.

The purpose of this study is to assess the safety and effectiveness of a Cala TWO Device on brain metabolism in essential tremor subjects scheduled to undergo deep brain stimulation surgery.

The aim of this feasibility study is to investigate whether we can improve sleep quality in patients who have DBS devices implanted for existing neurological indications by delivering targeted stimulation patterns during specific stages of sleep using their existing DBS device. We will only use electrical stimulation frequencies that have been proven to be safe for patients. We will perform these studies in patients admitted to the hospital in order to examine the structure and quality of sleep as well as how alert patients are when they wake up, while also monitoring physiological markers such as brainwave activity, ...

The purpose of this post-approval study is to further evaluate the long-term safety and effectiveness of Medtronic DBS therapy for epilepsy on seizure reduction in newly implanted participants through 3 years of follow-up in different geographic populations.

The proposed study seeks to obtain preliminary signal of the tolerability and efficacy of transcranial direct current stimulation (tDCS) for depressive symptoms in a sample of adolescents with depression and epilepsy. Additionally, effects of tDCS will be assessed via electroencephalographic, cognitive, and psychosocial measures.

The purpose of this study is to evaluate the safety and effectiveness of Boston Scientific's Vercise Deep Brain Stimulation (DBS) system in the treatment of patients with with advanced, levodopa-responsive bilateral Parkinson's disease (PD) which is not adequately controlled with medication.

The purpose of this study is to investigate the effects of subthalamic nucleus and globus pallidus interna deep brain stimulation on bowel symptoms and the ability to smell things in patients with Parkinson disease and constipation.

The purpose of this study is to gather information regarding the use of rTMS as a treatment for depression in adolescents with Major Depressive Disorder. The investigators also hope to learn if measures of brain activity (cortical excitability and inhibition) collected with transcranial magnetic stimulation (TMS) can be used to identify which patients will benefit from certain types of rTMS treatment. 

The primary purpose of this study is to understand how epilepsy patients think about neuromodulation in relation to concepts of neuroexceptionalism and the self.

The purpose of this study is to understand how electrical stimulation of the brain can modulate and suppress interictal epileptiform activity as a step on the path to developing new therapies for epilepsy.

The purpose of this study is to use functional imaging to study the mechanisms of the anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS).

The purpose of this study is to to use functional imaging to study the mechanisms of anterior thalamic nucleus (ANT) Deep Brain Stimulation (DBS).

The purpose of this study is to determine return to baseline (RTB) period after an elective craniotomy procedure using the ImPACT testing assessment.