A Study Evaluating the Use of Thalamic Deep Brain Stimulation (DBS) in the Treatment of Tremor


About this study

The purpose of this study is to directly compare the predictability of tremor reduction between two thalamic Deep Brain Stimulation (DBS) strategies.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Diagnosis of refractory essential tremor scheduled for unilateral thalamic deep brain stimulator placement.
  • Age ≥ 18 years old.

Exclusion Criteria: 

  • Prior deep brain stimulator, stereotactic radiosurgery, or focused ultrasound procedure for treatment of tremor.
  • Presence of concomitant movement disorder (e.g. Parkinson’s disease, dystonia, etc.).
  • Known pre-existing structural brain abnormality (e.g, infarction, tumor, prior brain surgery, etc.).
  • Contraindication to 3 Tesla brain MRI (e.g. incompatible implanted device).
  • Pregnant.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Erik Middlebrooks, M.D.

Closed for enrollment

More information


Publications are currently not available

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